4,5-二氢-6-甲基哒嗪-3(2H)-酮合成路线 （共 22 条）
反应条件
hydrazine carboxylic acid ester T=90°C; 1.5 h; Green chemistry;
参考文献
Lee, Byeongno; Kang, Philjun; Lee, Kyu Hyung; Cho, Jaeheung; Nam, Wonwoo; Lee, Won Koo; Hur, Nam Hwi
Tetrahedron Letters, 2013 , vol. 54, # 11 p. 1384 - 1388
反应条件
hydrazine hydrate in methanol T=20 - 60°C; 2.25 h;
参考文献
Shionogi and Co., Ltd.; KAI, Hiroyuki; ENDOH, Takeshi; JIKIHARA, Sae; ASAHI, Kentaro; HORIGUCHI, Tohru
Patent: EP2604260 A1, 2013 ;
Location in patent: Paragraph 0425; 0426 ;
反应条件
hydrazine hydrate in ethanol 4 h; Heating;
参考文献
Vlaovic, Djordje; Cetkovic, Gordana; Juranic, Ivan; Balaz, Jelica; Lajsic, Stevan; Djokovic, Dejan
Monatshefte fuer Chemie, 1990 , vol. 121, # 11 p. 931 - 939
反应条件
mesityl nitrile oxide in tetrahydrofuran T=20°C; 20 h;
参考文献
Abouricha; Rakib; Benchat; Alaoui; Allouchi; El Bali
Synthetic Communications, 2005 , vol. 35, # 16 p. 2213 - 2221
反应条件
hydrazine hydrate in methanol 16 h; Ambient temperature;
参考文献
Reichelt, I.; Reissig, H.-U.
Synthesis, 1984 , # 9 p. 786 - 787
反应条件
1: Et3N, DMAP / CH2Cl2 / 24 h / Ambient temperature 2: DIPEA / CH2Cl2 / 24 h / Ambient temperature 3: 1.) Me2BBr / 1.) CH2Cl2, -78 deg C, 1 h; 2.) -78 deg C, 1 h 4: N-iodosuccinimide, trifluoromethanesulfonic acid / CH2Cl2; tetrahydrofuran / 0.03 h / 0 °C 5: NH2NH2*H2O / acetic acid; ethyl acetate; pyridine / 0.03 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 45 p. 7825 - 7828
反应条件
pyridine; hydrazine hydrate; acetic acid 2 h;
参考文献
Chen, Chih-Hau; Chen, Wei-Yu; Chen, Yu-Chie; Lee, Ming-Juan; Huang, Chyuan-Der; Chanda, Kaushik; Sun, Chung-Ming
Australian Journal of Chemistry, 2010 , vol. 63, # 2 p. 227 - 235
反应条件
1: DIPEA / CH2Cl2 / 24 h / Ambient temperature 2: 1.) Me2BBr / 1.) CH2Cl2, -78 deg C, 1 h; 2.) -78 deg C, 1 h 3: N-iodosuccinimide, trifluoromethanesulfonic acid / CH2Cl2; tetrahydrofuran / 0.03 h / 0 °C 4: NH2NH2*H2O / acetic acid; ethyl acetate; pyridine / 0.03 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 45 p. 7825 - 7828
反应条件
1: N-iodosuccinimide, trifluoromethanesulfonic acid / CH2Cl2; tetrahydrofuran / 0.03 h / 0 °C 2: NH2NH2*H2O / acetic acid; ethyl acetate; pyridine / 0.03 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 45 p. 7825 - 7828
反应条件
1: DIPEA / CH2Cl2 / 24 h / Ambient temperature 2: 1.) Me2BBr / 1.) CH2Cl2, -78 deg C, 1 h; 2.) -78 deg C, 1 h 3: N-iodosuccinimide, trifluoromethanesulfonic acid / CH2Cl2; tetrahydrofuran / 0.03 h / 0 °C 4: NH2NH2*H2O / acetic acid; ethyl acetate; pyridine / 0.03 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 45 p. 7825 - 7828
