1,4-二碘-2,5-二甲氧基苯合成路线 （共 24 条）
反应条件
1: 1.) n-BuLi / 1.) ether, hexane, 10 min, 2.) ether, hexane, a) RT, 10 min, b) reflux, 10 min
2: 40 percent / ammonium acetate / 6 h / Heating
3: 52 percent / electrolytic Fe, AcOH / 0.5 h / Heating
View Scheme
参考文献
Sargent, Thornton; Shulgin, Alexander T.; Mathis, Chester A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1071 - 1077
反应条件
nitric acid; acetic acid
参考文献
Robinson
Journal of the Chemical Society, 1916 , vol. 109, p. 1087
参考文献
Robinson
Journal of the Chemical Society, 1916 , vol. 109, p. 1087
反应条件
1: potassium fluoride; tris(4-methylphenyl)-phosphine; bis(dibenzylideneacetone)-palladium(0) / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere
2: boron tribromide / dichloromethane / 48 h / -78 - 20 °C / Inert atmosphere
View Scheme
参考文献
Fuentes, Noelia; Cienfuegos, Luis Alvarez De; Parra, Andres; Choquesillo-Lazarte, Duane; Garcia-Ruiz, Juan M.; Marcos, M. Luisa; Bunuel, Elena; Ribagorda, Maria; Carreno, M. Carmen; Cardenas, Diego J.; Cuerva, Juan M.
Chemical Communications, 2011 , vol. 47, # 5 p. 1586 - 1588
