(2E,4E,6Z)-2,4,6-癸三烯酸甲酯合成路线 （共 11 条）
反应条件
1: phosphonoacetic acid P,P-bis(2,2,2-trifluoroethyl)methyl ester With sodium hexamethyldisilazane; 18-crown-6 ether in tetrahydrofuran; toluene T=-70°C; 0.25 h; 2: trans,trans-2,4-octadienal in tetrahydrofuran; toluene T=-75°C; Horner-Wadsworth-Emmons olefination; 1 h;
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
1: phosphonoacetic acid P,P-bis(2,2,2-trifluoroethyl)methyl ester With sodium hexamethyldisilazane; 18-crown-6 ether in tetrahydrofuran; toluene T=-70°C; 0.25 h; 2: trans,cis-2,4-octadienal in tetrahydrofuran; toluene T=-75°C; Horner-Wadsworth-Emmons olefination; 1 h;
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
1: p-toluenesulfonic acid monohydrate / H2O; acetone / 0.5 h / 0 - 5 °C 2: K2CO3 / H2O / 20 °C View Scheme
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
1: p-toluenesulfonic acid monohydrate / H2O; acetone / 0.5 h / 0 - 5 °C 2: K2CO3 / H2O / 20 °C View Scheme
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
potassium carbonate in water T=20°C; Horner-Wadsworth-Emmons olefination;
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
potassium carbonate in water T=20°C; Horner-Wadsworth-Emmons olefination; Title compound not separated from byproducts;
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
1: 90 percent / pyridinium p-toluenesulfonate / methanol / 50 - 55 °C 2: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / -60 - 0 °C 3: CH2Cl2 / 20 °C View Scheme
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
1.1: dicyclohexylborane / tetrahydrofuran / -20 - 20 °C 1.2: 76 percent / NaOH; H2O2 / H2O / 0 - 30 °C 2.1: 90 percent / pyridinium p-toluenesulfonate / methanol / 50 - 55 °C 3.1: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / -60 - 0 °C 4.1: CH2Cl2 / 20 °C View Scheme
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
1.1: 91 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 4 h / 25 °C 2.1: dicyclohexylborane / tetrahydrofuran / -20 - 20 °C 2.2: 76 percent / NaOH; H2O2 / H2O / 0 - 30 °C 3.1: 90 percent / pyridinium p-toluenesulfonate / methanol / 50 - 55 °C 4.1: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / -60 - 0 °C 5.1: CH2Cl2 / 20 °C View Scheme
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
反应条件
in dichloromethane T=20°C; Wittig reaction; Title compound not separated from byproducts;
参考文献
Khrimian, Ashot
Tetrahedron, 2005 , vol. 61, # 15 p. 3651 - 3657
