5-氨基-1-(4-氟苯基)-1H-吡唑-4-甲腈合成路线 （共 8 条）
参考文献
Moyano, Elizabeth L.; Colomer, Juan Pablo; Yranzo, Gloria I.
European Journal of Organic Chemistry, 2008 , # 19 p. 3377 - 3381
反应条件
in ethanol T=105°C; 0.333333 h; microwave irradiation;
参考文献
Daniels, R. Nathan; Kim, Kwangho; Lebois, Evan P.; Muchalski, Hubert; Hughes, Mary; Lindsley, Craig W.
Tetrahedron Letters, 2008 , vol. 49, # 2 p. 305 - 310
反应条件
1: 1.) NaNO2, HCl, 2.) SnCl2, HCl / 1.) H2O, 0 deg C, 2.) H2O, RT, 1 h 2: 56 percent / ethanol / 1 h / Heating View Scheme
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
参考文献
Harden; Quinn; Scammells
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2892 - 2898
反应条件
hydrogenchloride; acetic acid; sodium nitrite in water T=20°C; 20 h;
参考文献
Moyano, Elizabeth L.; Colomer, Juan Pablo; Yranzo, Gloria I.
European Journal of Organic Chemistry, 2008 , # 19 p. 3377 - 3381
反应条件
tert.-butylnitrite in tetrahydrofuran 2 h; Reflux;
参考文献
Dos Santos, Mauricio S.; Bernardino, Alice M. R.; Pinheiro, Luiz C. S.; Canto-Cavalheiro, Marilene M.; Leon, Leonor L.
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 6 p. 1425 - 1428
反应条件
hydrogenchloride; acetic acid; sodium nitrite in water T=20°C; 20 h;
参考文献
Moyano, Elizabeth L.; Colomer, Juan Pablo; Yranzo, Gloria I.
European Journal of Organic Chemistry, 2008 , # 19 p. 3377 - 3381
反应条件
sulfuric acid
T=0°C; 1 h;
参考文献
Daniels, R. Nathan; Kim, Kwangho; Lebois, Evan P.; Muchalski, Hubert; Hughes, Mary; Lindsley, Craig W.
Tetrahedron Letters, 2008 , vol. 49, # 2 p. 305 - 310
