2,4-二甲氧基-5-甲基嘧啶合成路线 （共 11 条）
反应条件
1: 5-bromo-2,4-dimethoxy-pyrimidine With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-20°C; 2 h; Inert atmosphere; 2: With CuCN*2LiCl in tetrahydrofuran T=-30°C; 3: methyl iodide in tetrahydrofuran T=20°C; Cooling;
参考文献
Boudet, Nadege; Dubbaka, Srinivas Reddy; Knochel, Paul
Organic Letters, 2008 , vol. 10, # 9 p. 1715 - 1718
反应条件
1: 2,4-dimethoxypyrimidine With n-butyllithium; CuCl2*TMEDA; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexanes T=20°C; 2 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; hexanes T=0 - 30°C; 16 h; Inert atmosphere;
参考文献
Nguyen, Tan Tai; Marquise, Nada; Chevallier, Floris; Mongin, Florence
Chemistry - A European Journal, 2011 , vol. 17, # 37 p. 10405 - 10416
反应条件
1: 4-methoxy-5-methyl-2(1H)-pyrimidinone With lithium hydride in N,N-dimethyl-formamide T=60°C; 0.5 h; 2: dimethyl sulfate in N,N-dimethyl-formamide T=60°C; 48 h;
参考文献
Gambacorta, Augusto; Tofani, Daniela; Loreto, Maria Antonietta; Gasperi, Tecla; Bernini, Roberta
Tetrahedron, 2006 , vol. 62, # 29 p. 6848 - 6854
参考文献
Schmidt-Nickels; Johnson
Journal of the American Chemical Society, 1930 , vol. 52, p. 4511,4514
参考文献
Saneyoshi; Watanabe
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 7 p. 2673 - 2678
反应条件
hydrogenchloride; ethanol; zinc
参考文献
Gerngross
Chemische Berichte, 1905 , vol. 38, p. 3397
参考文献
Gerngross
Chemische Berichte, 1905 , vol. 38, p. 3397
参考文献
Gerngross
Chemische Berichte, 1905 , vol. 38, p. 3397
反应条件
2,6-dimethylpyridine; dipotassium peroxodisulfate; sulfuric acid; copper(II) sulfate in water; acetonitrile T=80°C; 1 h;
参考文献
Coutouli-Argyropoulou, Evdoxia; Zachariadou, Christina
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 6 p. 1135 - 1142
反应条件
1: 34 percent / Na2CO3 / CH2Cl2 / 24 h / Ambient temperature 2: 17 percent / 2M NaOH / 26 h / Ambient temperature View Scheme
参考文献
Abrams; Ho; Chu
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 5 p. 947 - 951
