2-羟基甲基-4-吡啶甲腈合成路线 （共 12 条）
反应条件
1: With sulfuric acid 0.5 h; Heating / reflux; 2: With (NH4)2S2O8 in water 1.5 h; Heating / reflux; 3: With potassium carbonate in water pH=9;
参考文献
SHIONOGI and CO., LTD.; EURO-CELTIQUE S.A
Patent: WO2008/8398 A2, 2008 ;
Location in patent: Page/Page column 356 ;
反应条件
sulfuric acid in tetrahydrofuran 20 h; Heating;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
参考文献
Smith Kline and French Laboratories Limited
Patent: US4385058 A1, 1983 ;
US 4385058 A
反应条件
1: 4-pyridinecarbonitrile With sulfuric acid in methanol; water T=20°C; 0.166667 h; 2: With iron(II) sulfate in methanol; water 2.33333 h; 3: hydroxylamine-o-sulphonic acid With sulfuric acid; iron(II) sulfate in methanol; water 3 h; Product distribution / selectivity;
参考文献
KUDOS PHARMACEUTICALS LIMITED
Patent: WO2006/21801 A1, 2006 ;
Location in patent: Page/Page column 65-66 ;
WO 2006/021801 A1
反应条件
in methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water
参考文献
Pharmacia and Upjohn Company
Patent: US6043248 A1, 2000 ;
反应条件
1: CH2Cl2 / 1.5 h / Ambient temperature 2: aq. (NH4)2S2O8 / 1 h / Heating View Scheme
参考文献
Katz, R B; Mistry, J; Mitchell, M B
Synthetic Communications, 1989 , vol. 19, # 1, 2 p. 317 - 326
反应条件
1: 40.01 g / 18 h / Ambient temperature 2: ethanol; H2O / 0.5 h / 48 - 50 °C 3: 96 percent / m-chloroperbenzoic acid / CHCl3 / 4 h / Ambient temperature 4: 63 percent / Heating 5: 68 percent / aq. H2SO4 / tetrahydrofuran / 20 h / Heating View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 96 percent / m-chloroperbenzoic acid / CHCl3 / 4 h / Ambient temperature 2: 63 percent / Heating 3: 68 percent / aq. H2SO4 / tetrahydrofuran / 20 h / Heating View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 63 percent / Heating 2: 68 percent / aq. H2SO4 / tetrahydrofuran / 20 h / Heating View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: ethanol; H2O / 0.5 h / 48 - 50 °C 2: 96 percent / m-chloroperbenzoic acid / CHCl3 / 4 h / Ambient temperature 3: 63 percent / Heating 4: 68 percent / aq. H2SO4 / tetrahydrofuran / 20 h / Heating View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
