2-甲氧基萘-1-甲酰氯合成路线 （共 11 条）
反应条件
1: 41 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 2: acetonitrile / 20 °C / UV-irradiation View Scheme
参考文献
Najiwara, Toshihiro; Hashimoto, Ji-ichiro; Segawa, Katsunori; Sakuragi, Hirochika
Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 3 p. 575 - 585
参考文献
Fuson; Chadwick
Journal of Organic Chemistry, 1948 , vol. 13, p. 484,485
反应条件
1: Et3N / 1,2-dichloro-ethane
2: thionyl chloride / CH2Cl2; benzene / 4 h / Ambient temperature
3: 100 percent / tetrahydrofuran / Ambient temperature
4: 1.) methyl triflate, 2.) NaBH4, 3.) oxalic acid
View Scheme
参考文献
Gant, Thomas G.; Meyers
Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 1010 - 1015
反应条件
1: Et3N / 1,2-dichloro-ethane
2: thionyl chloride / CH2Cl2; benzene / 4 h / Ambient temperature
View Scheme
参考文献
Gant, Thomas G.; Meyers
Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 1010 - 1015
反应条件
2: diethyl ether; benzene
3: H2SO4
View Scheme
参考文献
Fuson; Wassmundt
Journal of the American Chemical Society, 1956 , vol. 78, p. 5409,5411
反应条件
1: in tetrahydrofuran; n-heptane
T=0°C; 0.333333 h;
2: With water; ammonium chloride in tetrahydrofuran; n-heptane
参考文献
GENENTECH, INC.
Patent: WO2006/69063 A1, 2006 ;
Location in patent: Page/Page column 64 ;
WO 2006/069063 A1
参考文献
Bretscher; Rule; Spence
Journal of the Chemical Society, 1928 , p. 1500
Full Text Show Details
Najiwara, Toshihiro; Hashimoto, Ji-ichiro; Segawa, Katsunori; Sakuragi, Hirochika
Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 3 p. 575 - 585
反应条件
thionyl chloride
2 h; Heating / reflux;
参考文献
NEUROGEN CORPORATION; GAO, Yang; HUTCHISON, Alan; PETERSON, John; PRINGLE, Wallace; THURKAUF, Andrew; YOON, Taeyoung; ZHAO, He
Patent: WO2003/82826 A1, 2003 ;
Location in patent: Page/Page column 51 ;
WO 03/082826 A1
反应条件
1: 1.) t-BuLi / 1.) THF, pentane, -78 deg C, 1 h, 2.) THF, pentane, from -78 deg C to RT, 1 h
2: oxalyl chloride / CH2Cl2 / 5 h
View Scheme
参考文献
Gant, Thomas G.; Meyers
Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 1010 - 1015
反应条件
1: 90 percent / NaOH / methanol; H2O / 48 h / Heating
2: thionyl chloride / 3.5 h / 60 °C
View Scheme
参考文献
Ahmed, Anjum; Bragg, Ryan A.; Clayden, Jonathan; Lai, Lai Wah; McCarthy, Catherine; Pink, Jennifer H.; Westlund, Neil; Yasin, Samreen A.
Tetrahedron, 1998 , vol. 54, # 43 p. 13277 - 13294
