N-叔丁氧羰基-L-蛋氨醇合成路线 （共 13 条）
反应条件
sodium tetrahydroborate; iodine in tetrahydrofuran; methanol T=0 - 5°C; 2 h; Reflux;
参考文献
ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD.; Pan, Xianhua; Li, Weijin; Zhang, Qunhui; Ruan, Libo; Yu, Wansheng; Deng, Fei; Ma, Tianhua; Huang, Mingwang; He, Minhuan
Patent: US2013/281695 A1, 2013 ;
Location in patent: Paragraph 0108-0110 ;
反应条件
triethylamine in 1,4-dioxane; water 2 h; Ambient temperature;
参考文献
Desimoni, Giovanni; Dusi, Guglielmo; Faita, Giuseppe; Quadrelli, Paolo; Righetti, PierPaolo
Tetrahedron, 1995 , vol. 51, # 14 p. 4131 - 4144
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=40°C;
参考文献
Tani,K.; Otsuka,S.; Kido,M.
Journal of the American Chemical Society, 1980 , vol. 102, p. 7394
反应条件
sodium tetrahydroborate; lithium chloride in tetrahydrofuran; ethanol
参考文献
Yang, Dezhi; Wang, Peng; Liu, Jianzhen; Xing, Hualu; Liu, Yang; Xie, Wencheng; Zhao, Guisen
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 366 - 373
反应条件
1: aq. NaOH / dioxane / 20 °C 2: NEt3 / tetrahydrofuran / -10 °C 3: 74 percent / NaBH4 / H2O / 0 °C View Scheme
参考文献
Correa; Denis; Greene
Synthetic Communications, 1991 , vol. 21, # 1 p. 1 - 9
反应条件
2: 71 percent / LiAlH4 / tetrahydrofuran / 40 °C View Scheme
参考文献
Tani,K.; Otsuka,S.; Kido,M.
Journal of the American Chemical Society, 1980 , vol. 102, p. 7394
反应条件
1: aq. NaOH / dioxane / 20 °C 2: NEt3 / tetrahydrofuran / -10 °C 3: 74 percent / NaBH4 / H2O / 0 °C View Scheme
参考文献
Zhejiang Hisoar Pharmaceutical Co., Ltd; PAN, Xianhua; LI, Weijin; ZHANG, Qunhui; RUAN, Libo; YU, Wansheng; DENG, Fei; MA, Tianhua; HUANG, Mingwang; HE, Minhuan
Patent: EP2647624 A1, 2013 ;
反应条件
1.1: sodium hydroxide / water; acetonitrile / 12 h / 0 - 45 °C 1.2: pH 6 2.1: sodium tetrahydroborate; iodine; methanol / tetrahydrofuran / 2 h / 0 - 5 °C / |Reflux View Scheme
参考文献
ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD.; Pan, Xianhua; Li, Weijin; Zhang, Qunhui; Ruan, Libo; Yu, Wansheng; Deng, Fei; Ma, Tianhua; Huang, Mingwang; He, Minhuan
Patent: US2013/281695 A1, 2013 ;
反应条件
1: triethylamine / dichloromethane / 24 h / 25 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 25 °C View Scheme
参考文献
Bera, Saurav; Panda, Gautam
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 23 p. 3976 - 3985
反应条件
1: 95 percent / BF3*Et2O / acetone / Ambient temperature 2: 93 percent / NaIO4, NaHCO3 / methanol; H2O / 0 °C 3: 69 percent / various solvent(s) / 6 h / 175 - 180 °C 4: OsO4, NMO / acetone / Ambient temperature 5: NaIO4, SiO2 / CH2Cl2 / Ambient temperature View Scheme
参考文献
Ravi Kumar, Jalluri S.; Datta, Apurba
Tetrahedron Letters, 1997 , vol. 38, # 38 p. 6779 - 6780
