4-乙酰氨基-2-甲基硝基苯合成路线 （共 22 条）
反应条件
potassium permanganate; water
参考文献
Kalb et al.
Chemische Berichte, 1926 , vol. 59, p. 1864
反应条件
1: With arsenic pentoxide; sulfuric acid T=130°C; 20 h; 2: With ammonia in water pH=7 - 8;
参考文献
Huisgen
Justus Liebigs Annalen der Chemie, 1948 , vol. 559, p. 101,142
反应条件
1: 1.) H2SO4, arsenic acid; 2.) H2 / 2.) 10percent Pd-C / 1.) 130 deg C, 18 h; 2.) EtOH, 7 d 2: 90 percent / (CH3CO)2O / 2 h / Ambient temperature 3: 90 percent / LiAlH4 / tetrahydrofuran / 0 °C 4: 68 percent / HNO3, H2SO4 / 1 h / 0 °C View Scheme
参考文献
Lee; Hashimoto; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1857 - 1859
反应条件
1: 1.) H2SO4, arsenic acid; 2.) H2 / 2.) 10percent Pd-C / 1.) 130 deg C, 18 h; 2.) EtOH, 7 d 2: 90 percent / (CH3CO)2O / 2 h / Ambient temperature 3: 90 percent / LiAlH4 / tetrahydrofuran / 0 °C 4: 68 percent / HNO3, H2SO4 / 1 h / 0 °C 5: 80 percent / SnCl2, HCl / 1 h / 100 °C View Scheme
参考文献
Lee; Hashimoto; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1857 - 1859
参考文献
Wepster; Verkade
Recueil des Travaux Chimiques des Pays-Bas, 1949 , vol. 68, p. 88,89
参考文献
Byron,D.J. et al.
Journal of the Chemical Society, 1963 , p. 2246 - 2256
反应条件
1: (nitration) 2: SnCl2, aq. HCl View Scheme
参考文献
Byron,D.J. et al.
Journal of the Chemical Society, 1963 , p. 2246 - 2256
反应条件
1: 1.) H2SO4, arsenic acid; 2.) H2 / 2.) 10percent Pd-C / 1.) 130 deg C, 18 h; 2.) EtOH, 7 d 2: 90 percent / (CH3CO)2O / 2 h / Ambient temperature 3: 90 percent / LiAlH4 / tetrahydrofuran / 0 °C 4: 68 percent / HNO3, H2SO4 / 1 h / 0 °C 5: 80 percent / SnCl2, HCl / 1 h / 100 °C 6: ethanol / 2 h View Scheme
参考文献
Lee; Hashimoto; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1857 - 1859
反应条件
1: water; potassium permanganate 2: diluted hydrochloric acid View Scheme
参考文献
Hewitt; Mitchell
Journal of the Chemical Society, 1907 , vol. 91, p. 1264
反应条件
1: With arsenic pentoxide; sulfuric acid
T=130°C; 20 h;
2: With ammonia in water
pH=7 - 8;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/37796 A2, 2004 ;
Location in patent: Page 75 ;
WO 2004/037796 A2
