2,2-二甲基-[1,3]二恶烷-5,5-二甲酸二乙酯合成路线 （共 11 条）
参考文献
ICI Americas Inc.
Patent: US4701485 A1, 1987 ;
反应条件
sodium chloride in water; dimethyl sulfoxide 6 h; Heating;
参考文献
Dubois, Joelle; Foures, Christine; Bory, Sonia; Falcou, Serge; Gaudry, Michel; Marquet, Andree
Tetrahedron, 1991 , vol. 47, # 6 p. 1001 - 1012
反应条件
1: 74 percent / aq. NaCl / dimethylsulfoxide / 24 h / 180 °C 2: LiAlH4 / diethyl ether / 5 h / Ambient temperature View Scheme
参考文献
Bates, Hans Aaron; Farina, James; Tong, Michael
Journal of Organic Chemistry, 1986 , vol. 51, # 14 p. 2637 - 2641
反应条件
sulfuric acid in acetone
T=20°C; 19 h;
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
Location in patent: Page/Page column 16 ;
反应条件
sulfuric acid in 2,2-dimethoxy-propane
T=25°C; 48 h;
参考文献
Berthel, Steven Joseph; Kester, Robert Francis; Murphy, Douglas Eric; Prins, Thomas Jay; Ruebsam, Frank; Sarabu, Ramakanth; Tran, Chinh Viet; Vourloumis, Dionisios
Patent: US2008/21032 A1, 2008 ;
Location in patent: Page/Page column 81 ;
US 20080021032 A1
反应条件
phosphoric acid; sodium carbonate in acetone; benzene
参考文献
Thiokol Corporation
Patent: US4336408 A1, 1982 ;
反应条件
1: 74 percent / KHCO3 / H2O / 1 h / 20 °C
2: 90 percent / p-toluenesulfonic acid / acetone / 6 h / Heating
View Scheme
参考文献
Dubois, Joelle; Foures, Christine; Bory, Sonia; Falcou, Serge; Gaudry, Michel; Marquet, Andree
Tetrahedron, 1991 , vol. 47, # 6 p. 1001 - 1012
反应条件
lithium aluminium tetrahydride in diethyl ether
T=25°C; Reduction; 1 h;
参考文献
Ishihara, Jun; Yamamoto, Yuuko; Kanoh, Naoki; Murai, Akio
Tetrahedron Letters, 1999 , vol. 40, # 23 p. 4387 - 4390
反应条件
sodium chloride in dimethyl sulfoxide
T=180°C; 24 h;
参考文献
Iwata; Maezaki; Hattori; Fujita; Moritani; Takemoto; Tanaka; Imanishi
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 2 p. 339 - 345
反应条件
sodium chloride in water; dimethyl sulfoxide
6 h; Heating;
参考文献
Dubois, Joelle; Foures, Christine; Bory, Sonia; Falcou, Serge; Gaudry, Michel; Marquet, Andree
Tetrahedron, 1991 , vol. 47, # 6 p. 1001 - 1012
