保护的甲基-L-丝氨酸二环己基铵盐合成路线 （共 5 条）
反应条件
1: t-butyloxycarbonyl-L-serine With methanol; sodium hydride in tetrahydrofuran; mineral oil T=20°C; 1 h; 2: methyl iodide in tetrahydrofuran; methanol; mineral oil T=20°C; 38 h; 3: With citric acid in water pH=2;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2011/152273 A1, 2011 ;
Location in patent: Page/Page column 87 ;
反应条件
sodium hydrogencarbonate in methanol; water T=20°C;
参考文献
Oelke, Alexander J.; Antonietti, Francesca; Bertone, Leonardo; Cranwell, Philippa B.; France, David J.; Goss, Rebecca J. M.; Hofmann, Tatjana; Knauer, Stephan; Moss, Steven J.; Skelton, Paul C.; Turner, Richard M.; Wuitschik, Georg; Ley, Steven V.
Chemistry - A European Journal, 2011 , vol. 17, # 15 p. 4183 - 4194
反应条件
1: 97 percent / Et3N 2: proton sponge 3: NaOH / methanol View Scheme
参考文献
Sowinski, Jennifer A.; Toogood, Peter L.
Tetrahedron Letters, 1995 , vol. 36, # 1 p. 67 - 70
反应条件
1: proton sponge 2: NaOH / methanol View Scheme
参考文献
Sowinski, Jennifer A.; Toogood, Peter L.
Tetrahedron Letters, 1995 , vol. 36, # 1 p. 67 - 70
参考文献
Hodges,S.; Merrifield,R.B.
Journal of Organic Chemistry, 1974 , vol. 39, p. 1870 - 1872
