甲基2,2-双(4-羟基苯基)乙酸甲酯合成路线 （共 7 条）
反应条件
1: conc. H2SO4 / H2O / 18 h / 20 °C
2: conc. H2SO4 / 3 h / Heating
View Scheme
参考文献
Kolasa; Gunn; Bhatia; Basha; Craig; Stewart; Bouska; Harris; Hulkower; Malo; Bell; Carter; Brooks
Journal of Medicinal Chemistry, 2000 , vol. 43, # 17 p. 3322 - 3334
反应条件
hydrogenchloride
Heating;
参考文献
Nathansohn,G.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1420 - 1422
反应条件
1: sodium ethylate; ethanol / 180 °C
2: pyridine hydrochloride / 210 °C
3: diethyl ether
View Scheme
参考文献
Hubacher
Journal of Organic Chemistry, 1959 , vol. 24, p. 1949
反应条件
1: pyridine hydrochloride / 210 °C
2: diethyl ether
View Scheme
参考文献
Hubacher
Journal of Organic Chemistry, 1959 , vol. 24, p. 1949
反应条件
1: aq. H2SO4
2: (i) (alkaline hydrolysis), (ii) aq. HBr, AcOH
3: HCl / Heating
View Scheme
参考文献
Nathansohn,G.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1420 - 1422
反应条件
1: (i) (alkaline hydrolysis), (ii) aq. HBr, AcOH
2: HCl / Heating
View Scheme
参考文献
Nathansohn,G.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1420 - 1422
参考文献
Hubacher
Journal of Organic Chemistry, 1959 , vol. 24, p. 1949
