5-氯-2-硝基苯甲酸甲酯合成路线 （共 26 条）
反应条件
1.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C 2.1: 85 percent / pyridine / 20 °C 3.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C 4.1: t-BuOK / toluene / 0.5 h / Heating 4.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating 5.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C View Scheme
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C 2: 85 percent / pyridine / 20 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; JANAKIRAM REDDY, Maruthi; VAMSI KRISHNA, Bandi
Patent: WO2012/46244 A1, 2012 ;
反应条件
1: 78 percent / NEt3 / dimethylsulfoxide / Heating 2: 79 percent / aq. NaOH / tetrahydrofuran; methanol / Ambient temperature View Scheme
参考文献
Geddes, N. J.; Jurich, M. C.; Swalen, J. D.; Twieg, R.; Rabolt, J. F.
Journal of Chemical Physics, 1991 , vol. 94, # 2 p. 1603 - 1612
反应条件
1.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C
2.1: 85 percent / pyridine / 20 °C
3.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
4.1: t-BuOK / toluene / 0.5 h / Heating
4.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
View Scheme
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
1: 94 percent / dimethylformamide / 3.5 h / 100 °C
2: 58 percent / H2 / 10percent Pd-C / methanol / 760 Torr
View Scheme
参考文献
Lamara, Kaddour; Smalley, Robert K.
Tetrahedron, 1991 , vol. 47, # 12-13 p. 2277 - 2290
参考文献
Sevbo, D. P.; Stepanova, T. F.; Nekhoroshev, A. A.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, p. 1097 - 1101
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 6 p. 1268 - 1274
