N-叔丁基-(苯m乙烷)磺酰胺合成路线 （共 8 条）
反应条件
methanesulfonic acid; Trioxane; acetic anhydride in 1,2-dichloro-ethane T=35°C; 4 h;
参考文献
Orazi; Corral; Bravo
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1701 - 1708
反应条件
(i) KOtBu, THF, (ii) EtONO2; Multistep reaction;
参考文献
Truce,W.E.; Christensen,L.W.
Tetrahedron, 1969 , vol. 25, p. 181 - 189
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 16 h;
参考文献
F. HOFFMANN-LA ROCHE AG; FAUBER, Benjamin; RENE, Olivier
Patent: WO2013/92941 A1, 2013 ;
Location in patent: Page/Page column 50 ;
反应条件
in dichloromethane
T=25 - 30°C; 0.333333 h;
参考文献
Harger, Martin J.P.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3390 - 3395
反应条件
1: Phosphorus pentachloride
2: CHCl3; benzene
View Scheme
参考文献
Orazi; Corral; Bravo
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1701 - 1708
反应条件
in dichloromethane
T=30°C; 0.5 h;
参考文献
Harger, Martin J.P.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3390 - 3395
反应条件
1: 9 percent / Trioxane, CH3SO3H, Acetic anhydride / 1,2-dichloro-ethane / 4 h / 35 °C
2: 44 percent / Trifluoromethanesulphonic acid, Trifluoromethanesulphonic anhydride / 1,2-dichloro-ethane / 3 h / 35 °C
View Scheme
参考文献
Orazi; Corral; Bravo
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1701 - 1708
反应条件
1: 9 percent / Trioxane, CH3SO3H, Acetic anhydride / 1,2-dichloro-ethane / 4 h / 35 °C
2: 54 percent / CH3SO3H / acetic acid / 0.03 h / 35 °C / influence of react. time on the products, other time
View Scheme
参考文献
Orazi; Corral; Bravo
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1701 - 1708
