beta-甲基-2-苯基-6-苯并恶唑乙醇合成路线 （共 11 条）
反应条件
lithium aluminium tetrahydride in diethyl ether
Ambient temperature;
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: polyphosphoric acid / 0.33 h / 180 - 210 °C
2: NBS / CCl4 / 3 h / Heating; Irradiation
3: DMF / 7 h / Ambient temperature
4: aq. H2SO4 / 1.5 h / Heating
5: TsOH / benzene / 24 h / Heating
6: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
7: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: aq. H2SO4 / 1.5 h / Heating
2: TsOH / benzene / 24 h / Heating
3: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
4: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: TsOH / benzene / 24 h / Heating
2: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
3: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
2: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: 0.33 h / 200 - 210 °C
2: NBS / CCl4 / 3 h / Heating; Irradiation
3: DMF / 7 h / Ambient temperature
4: aq. H2SO4 / 1.5 h / Heating
5: TsOH / benzene / 24 h / Heating
6: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
7: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: NBS / CCl4 / 3 h / Heating; Irradiation
2: DMF / 7 h / Ambient temperature
3: aq. H2SO4 / 1.5 h / Heating
4: TsOH / benzene / 24 h / Heating
5: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
6: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: polyphosphoric acid / 0.33 h / 180 - 210 °C
2: NBS / CCl4 / 3 h / Heating; Irradiation
3: DMF / 7 h / Ambient temperature
4: aq. H2SO4 / 1.5 h / Heating
5: TsOH / benzene / 24 h / Heating
6: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
7: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: (i) Py, (ii) (heating)
2: NBS / CCl4 / 3 h / Heating; Irradiation
3: DMF / 7 h / Ambient temperature
4: aq. H2SO4 / 1.5 h / Heating
5: TsOH / benzene / 24 h / Heating
6: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
7: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: DMF / 7 h / Ambient temperature
2: aq. H2SO4 / 1.5 h / Heating
3: TsOH / benzene / 24 h / Heating
4: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
5: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
