(3alpha,5R,6beta,20S)-6-甲氧基-3,5-环孕烷-30-甲醇4-甲基苯磺酸酯合成路线 （共 2 条）
反应条件
1: 87 percent / KI / acetone 2: 92 percent / dimethylformamide / 3 h / Heating 3: 81 percent / butyllithium / tetrahydrofuran; pentane / Ambient temperature 4: 74 percent / Li, NH3, ethanol / tetrahydrofuran / 0.5 h / -78 °C 5: 87 percent / glacial AcOH / 6 h / Ambient temperature 6: 92 percent / K2Os2(OH)4, (DHQD)2PHAL, K2CO3, potassium ferricyanate, CH3SO2NH2 / H2O; 2-methyl-propan-2-ol / 96 h / Ambient temperature 7: 1) CH3SO2Cl, pyridine, 2) K2CO3 / 1) CH2Cl2, RT, 2) aq. CH3OH, RT, 18 h View Scheme
参考文献
Tomkinson, Nicholas C. O.; Willson, Timothy M.; Russel, Jonathon S.; Spencer, Thomas A.
Journal of Organic Chemistry, 1998 , vol. 63, # 26 p. 9919 - 9923
反应条件
Multi-step reaction with 2 steps 1.1: ozone / CH2Cl2; methanol / 12 h / -78 °C1.2: 69 percent / NaBH4 / CH2Cl2; methanol; aq. ethanol / 20 °C2.1: pyridine
参考文献
Spencer, Thomas A.; Li, Dansu; Russel, Jonathon S.; Tomkinson, Nicholas C. O.; Willson, Timothy M. Journal of Organic Chemistry, 2000 , vol. 65, # 7 p. 1919 - 1923
