N-邻苯二甲酰基-L-苯丙氨酸合成路线 （共 20 条）
反应条件
in water 0.5 h; microwave irradiation;
参考文献
Shendage, Deepak M.; Froehlich, Roland; Haufe, Guenter
Organic Letters, 2004 , vol. 6, # 21 p. 3675 - 3678
反应条件
potassium carbonate in acetonitrile T=20°C; 3 h;
参考文献
Casimir, J Richard; Guichard, Gilles; Briand, Jean-Paul
The Journal of organic chemistry, 2002 , vol. 67, # 11 p. 3764 - 3768
反应条件
N-ethyl-N,N-diisopropylamine in water; acetonitrile 0.166667 h; Ambient temperature;
参考文献
Kehler, Jan; Breuer, Eli
Synthesis, 1998 , # 10 p. 1419 - 1420
反应条件
sodium carbonate in water; acetonitrile T=20°C;
参考文献
Asgatay, Saaidia; Champion, Christine; Marloie, Gael; Drujon, Thierry; Senamaud-Beaufort, Catherine; Ceccaldi, Alexandre; Erdmann, Alexandre; Rajavelu, Arumugam; Schambel, Philippe; Jeltsch, Albert; Lequin, Olivier; Karoyan, Philippe; Arimondo, Paola B.; Guianvarc'H, Dominique
Journal of Medicinal Chemistry, 2014 , vol. 57, # 2 p. 421 - 434
反应条件
sodium carbonate in ethyl acetate
参考文献
Aitken, R. Alan; Cooper, Harris R.; Mehrotra, Amit P.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 5 p. 475 - 483
反应条件
1: 98 percent / DCC / 1,2-dimethoxy-ethane / 6 h / 0 °C 2: 100 percent / aq. K2CO3 / acetonitrile / 3 h / 20 °C View Scheme
参考文献
Casimir, J Richard; Guichard, Gilles; Briand, Jean-Paul
The Journal of organic chemistry, 2002 , vol. 67, # 11 p. 3764 - 3768
反应条件
1: 78 percent / 0.25 h / Ambient temperature 2: 80 percent / (i-Pr)2NEt / acetonitrile; H2O / 0.17 h / Ambient temperature View Scheme
参考文献
Kehler, Jan; Breuer, Eli
Synthesis, 1998 , # 10 p. 1419 - 1420
反应条件
1: 2-picoline; palladium (II) trifluoroacetate; trifluoroacetic acid; silver carbonate / 1,2-dichloro-ethane / 20 h / 100 °C 2: sodium nitrite; acetic acid; acetic anhydride / 20 h / 0 - 20 °C View Scheme
参考文献
He, Jian; Li, Suhua; Deng, Youqian; Fu, Haiyan; Laforteza, Brian N.; Spangler, Jillian E.; Homs, Anna; Yu, Jin-Quan
Science, 2014 , vol. 343, # 6176 p. 1216 - 1220
反应条件
1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 4 h / |Reflux 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -20 °C 3.1: palladium diacetate; CuF2; N,N'-dimethyl-N,N'-propyleneurea / acetone / 24 h / 100 °C / |Inert atmosphere; |Schlenk technique 4.1: sodium nitrite; acetic acid / acetic anhydride / 48.5 h / -15 °C 4.2: 2 h / -15 °C 4.3: 2 h / 0 °C View Scheme
参考文献
Zhang, Qi; Chen, Kai; Rao, Weihao; Zhang, Yuejun; Chen, Fa-Jie; Shi, Bing-Feng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 51 p. 13588 - 13592
Angew. Chem., 2013 , vol. 125, # 51 p. 13833 - 13837,5
反应条件
1.1: sodium carbonate / water / 3 h / 20 °C 2.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 4 h / |Reflux 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -20 °C 4.1: palladium diacetate; CuF2; N,N'-dimethyl-N,N'-propyleneurea / acetone / 24 h / 100 °C / |Inert atmosphere; |Schlenk technique 5.1: sodium nitrite; acetic acid / acetic anhydride / 48.5 h / -15 °C 5.2: 2 h / -15 °C 5.3: 2 h / 0 °C View Scheme
参考文献
Zhang, Qi; Chen, Kai; Rao, Weihao; Zhang, Yuejun; Chen, Fa-Jie; Shi, Bing-Feng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 51 p. 13588 - 13592
Angew. Chem., 2013 , vol. 125, # 51 p. 13833 - 13837,5
