1-乙炔基-2,3,4,5,6-五氟苯合成路线 （共 19 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; oxygen; copper(l) chloride in acetone 3.5 h; Ambient temperature;
参考文献
Zhang, Yadong; Wen, Jianxun
Journal of Fluorine Chemistry, 1991 , vol. 51, # 1 p. 75 - 82
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 16 h / 20 - 50 °C / |Inert atmosphere; |Schlenk technique 2: Au/Carbon G-60 catalyst / toluene / 48 h / 120 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Perea-Buceta, Jesus E.; Wirtanen, Tom; Laukkanen, Otto-Ville; Maekelae, Mikko K.; Nieger, Martin; Melchionna, Michele; Huittinen, Nina; Lopez-Sanchez, Jose A.; Helaja, Juho
Angewandte Chemie - International Edition, 2013 , vol. 52, # 45 p. 11835 - 11839
Angew. Chem., 2013 , vol. 125, # 45 p. 12051 - 12055,5
反应条件
potassium hydroxide in methanol
0.416667 h; Ambient temperature;
参考文献
Neenan, Thomas X.; Whitesides, George M.
Journal of Organic Chemistry, 1988 , vol. 53, # 11 p. 2489 - 2496
反应条件
1: diisopropylamine, triphenylphosphine, copper(I) iodide / Pd(PPh3)2Cl2
2: KOH / methanol / Ambient temperature
View Scheme
参考文献
Crisp; Flynn
Journal of Organic Chemistry, 1993 , vol. 58, # 24 p. 6614 - 6619
反应条件
1: 91 percent / Et3N / (Ph3P)2PdCl2, CuI / 48 h / 30 - 35 °C
2: 69 percent / aq. 0.05 M NaOH / methanol / 3 h / 24 °C
View Scheme
参考文献
Zhang, Yadong; Wen, Jianxun
Synthesis, 1990 , # 8 p. 727 - 728
反应条件
1: With n-butyllithium in hexane
T=-78 - 20°C; Fritsch-Buttenberg-Wiechell rearrangement; 4 h; Inert atmosphere;
2: Inert atmosphere;
参考文献
Tykwinski, Rik R.; Kendall, Jamie; McDonald, Robert
Synlett, 2009 , # 13 p. 2068 - 2075
参考文献
Okuhara, K.; Kodaira, K.
Journal of Fluorine Chemistry, 1983 , vol. 23, p. 497
反应条件
magnesium in tetrahydrofuran
Heating;
参考文献
Coe,P.L. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 597 - 603
反应条件
1: AlCl3 / 120 °C
2: Mg / tetrahydrofuran / Heating
View Scheme
参考文献
Coe,P.L. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 597 - 603
反应条件
1: PCl5 / 100 °C
2: AlCl3 / 120 °C
3: Mg / tetrahydrofuran / Heating
View Scheme
参考文献
Coe,P.L. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 597 - 603
