2-氨基-3-甲氧基苯甲酸甲酯合成路线 （共 21 条）
反应条件
1: (i) aq. HCl, NaNO2, (ii) CuCl, aq. HCl 2: aq. NaOH View Scheme
参考文献
Cleaver,L. et al.
Australian Journal of Chemistry, 1976 , vol. 29, p. 2003 - 2021
反应条件
1: diethyl ether 2: iodine; toluene View Scheme
参考文献
Albert; Hampton
Journal of the Chemical Society, 1952 , p. 4985,4990
反应条件
1: N-methyl-N'-nitro-N-nitroso-guanidine With potassium hydroxide in diethyl ether; water
T=0°C;
2: 2-amino-3-methoxy-benzoic acid in diethyl ether; acetone
参考文献
AMR Technology, Inc.
Patent: US2006/183769 A1, 2006 ;
Location in patent: Page/Page column 36 ;
反应条件
methanol; nickel
Hydrogenation;
参考文献
Curd et al.
Journal of the Chemical Society, 1948 , p. 1759,1765
反应条件
sodium hydroxide
2 h; Reflux;
参考文献
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; GLICK, Gary, D.; HURD, Alexander, Ross; VAN HUIS, Chad, Alan
Patent: WO2011/35124 A1, 2011 ;
Location in patent: Page/Page column 83 ;
WO 2011/035124 A1
反应条件
hydrogenchloride
12 h; Heating;
参考文献
Ramesh, M.; Shanmugam, P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 602 - 604
反应条件
1: N-methyl-N-nitroso-p-toluene-sulphonamide With potassium hydroxide in diethyl ether; water
2: 2-amino-3-methoxy-benzoic acid in diethyl ether
1 h;
参考文献
Schuler, Elisabeth; Juanico, Nacho; Teixido, Jordi; Michelotti, Enrique L.; Borrell, Jose I.
Heterocycles, 2006 , vol. 67, # 1 p. 161 - 173
反应条件
in acetone
Ambient temperature;
参考文献
Macdonald, Simon J. F.; McKenzie, Thomas C.; Hassen, Wesley D.
Journal of the Chemical Society, Chemical Communications, 1987 , # 20 p. 1528 - 1530
反应条件
1: 1.) nBuLi / 1.) THF, r.t.; 2.) r.t.
2: 87 percent / 25percent HCl / Heating
3: 92 percent / acetone / Ambient temperature
View Scheme
参考文献
Macdonald, Simon J. F.; McKenzie, Thomas C.; Hassen, Wesley D.
Journal of the Chemical Society, Chemical Communications, 1987 , # 20 p. 1528 - 1530
反应条件
1: 98 percent / aq. Na2CO3 / CH2Cl2 / Ambient temperature
2: 1.) nBuLi / 1.) THF, r.t.; 2.) r.t.
3: 87 percent / 25percent HCl / Heating
4: 92 percent / acetone / Ambient temperature
View Scheme
参考文献
Macdonald, Simon J. F.; McKenzie, Thomas C.; Hassen, Wesley D.
Journal of the Chemical Society, Chemical Communications, 1987 , # 20 p. 1528 - 1530
