4-氨基-N-丁基苯甲酰胺合成路线 （共 5 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=2327.2 Torr; 3 h;
参考文献
Clark; Wells; Sansom; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 779 - 782
反应条件
formic acid; [Ru(II)(2,2’-bipyridine)3]Cl2; diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; N-ethyl-N,N-diisopropylamine in dichloromethane
T=25°C; 2 h; Irradiation; chemoselective reaction;
参考文献
Chen, Yiyun; Kamlet, Adam S.; Steinman, Jonathan B.; Liu, David R.
Nature Chemistry, 2011 , vol. 3, # 2 p. 146 - 153
反应条件
1: 70 percent / 20percent (w/v) K2CO3 / tetrahydrofuran / 12 h / Heating
2: 80 percent / H2 / 5percent Pd/C / ethanol / 3 h / 2327.2 Torr
View Scheme
参考文献
Clark; Wells; Sansom; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 779 - 782
参考文献
Centaur Pharmaceuticals, Inc.
Patent: US5643965 A1, 1997 ;
反应条件
1: thionyl chloride / 3 h / |Reflux
2: triethylamine / dichloromethane / 0 - 20 °C
3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C
View Scheme
参考文献
Sun, Ranfeng; Wang, Ziwen; Li, Yongqiang; Xiong, Lixia; Liu, Yuxiu; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2013 , vol. 61, # 3 p. 517 - 522
