(S)-(+)-1-(2-吡咯烷甲基)吡咯烷合成路线 （共 15 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Dieter,R.K.; Tokles,M.
Journal of the American Chemical Society, 1987 , vol. 109, p. 2040
反应条件
lithium in tetrahydrofuran; ethanol; ammonia 0.25 h; Heating;
参考文献
Hendrie, Shirley K.; Leonard, John
Tetrahedron, 1987 , vol. 43, # 14 p. 3289 - 3294
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Amedjkouh, Mohamed; Ahlberg, Per
Tetrahedron Asymmetry, 2002 , vol. 13, # 20 p. 2229 - 2234
反应条件
1: With copper(l) iodide in 1,4-dioxane T=100°C; 18 h; Inert atmosphere; 2: With sodium tetrahydroborate in 1,4-dioxane; methanol T=0 - 25°C; 2 h;
参考文献
Gurubrahamam, Ramani; Periasamy, Mariappan
Journal of Organic Chemistry, 2013 , vol. 78, # 4 p. 1463 - 1470
反应条件
1: 73 percent / ClCOOEt, Et3N / tetrahydrofuran 2: trifluoroacetic acid / 1 h / 20 °C 3: 67 percent / LiAlH4 / tetrahydrofuran View Scheme
参考文献
Dieter,R.K.; Tokles,M.
Journal of the American Chemical Society, 1987 , vol. 109, p. 2040
反应条件
1: trifluoroacetic acid / 1 h / 20 °C 2: 67 percent / LiAlH4 / tetrahydrofuran View Scheme
参考文献
Dieter,R.K.; Tokles,M.
Journal of the American Chemical Society, 1987 , vol. 109, p. 2040
反应条件
1: 85 percent / NaOH / tetrahydrofuran 2: 73 percent / ClCOOEt, Et3N / tetrahydrofuran 3: trifluoroacetic acid / 1 h / 20 °C 4: 67 percent / LiAlH4 / tetrahydrofuran View Scheme
参考文献
Dieter,R.K.; Tokles,M.
Journal of the American Chemical Society, 1987 , vol. 109, p. 2040
反应条件
1: H2 / 5percent Pd/C / methanol 2: LiAlH4 / tetrahydrofuran / 20 h / Heating View Scheme
参考文献
Clarke, Sarah L.; McSweeney, Christina M.; McGlacken, Gerard P.
Tetrahedron Asymmetry, 2014 , vol. 25, # 4 p. 356 - 361
反应条件
1: 63 percent / DCC / CH2Cl2 / 0 deg C to r.t. 2: H2 / 5percent Pd/C / methanol 3: LiAlH4 / tetrahydrofuran / 20 h / Heating View Scheme
参考文献
Clarke, Sarah L.; McSweeney, Christina M.; McGlacken, Gerard P.
Tetrahedron Asymmetry, 2014 , vol. 25, # 4 p. 356 - 361
反应条件
1: 65 percent / triethylamine / CH2Cl2 / 24 h / Heating 2: 70 percent / DBU / toluene / 24 h / Heating 3: 68 percent / lithium / tetrahydrofuran; ethanol; liquid ammonia / 0.25 h / Heating View Scheme
参考文献
Alker; Doyle; Harwood; McGregor
Tetrahedron Asymmetry, 1990 , vol. 1, # 12 p. 877 - 880
