甲基-3-溴吡嗪-2-羧酸甲酯合成路线 （共 7 条）
反应条件
hydrogen bromide; bromine; sodium nitrite in water T=0°C; 0.25 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/49681 A2, 2006 ;
Location in patent: Page/Page column 45-46 ;
WO 2006/049681 A2
反应条件
1: sulfuric acid / 20 °C 2: sodium nitrite; bromine / water / 0 °C View Scheme
参考文献
Duan, Hongliang; Ning, Mengmeng; Chen, Xiaoyan; Zou, Qingan; Zhang, Liming; Feng, Ying; Zhang, Lina; Leng, Ying; Shen, Jianhua
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10475 - 10489
反应条件
water; sodium hydroxide in methanol T=20°C;
参考文献
Duan, Hongliang; Ning, Mengmeng; Chen, Xiaoyan; Zou, Qingan; Zhang, Liming; Feng, Ying; Zhang, Lina; Leng, Ying; Shen, Jianhua
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10475 - 10489
反应条件
toluene-4-sulfonic acid; aniline in water
参考文献
Schering Corporation
Patent: US4492702 A1, 1985 ;
反应条件
ethanol
T=125°C; anschliessend mit Methanol und konz. H2SO4;
参考文献
Ellingson; Henry
Journal of the American Chemical Society, 1949 , vol. 71, p. 2798
参考文献
MERCK and CO., INC.
Patent: WO2007/67511 A2, 2007 ;
Location in patent: Page/Page column 33 ;
WO 2007/067511 A2
反应条件
water; sodium hydroxide in methanol
T=20°C;
参考文献
Duan, Hongliang; Ning, Mengmeng; Chen, Xiaoyan; Zou, Qingan; Zhang, Liming; Feng, Ying; Zhang, Lina; Leng, Ying; Shen, Jianhua
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10475 - 10489
