丁氧羰基-3 ,4-脱氢脯氨酸羟基合成路线 （共 26 条）
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water
参考文献
GENENTECH, INC.
Patent: WO2008/24725 A1, 2008 ;
Location in patent: Page/Page column 132 ;
WO 2008/024725 A1
反应条件
lithium hydroxide in tetrahydrofuran 18 h; Ambient temperature;
参考文献
Shangguan, Ning; Joullie, Madeleine
Tetrahedron Letters, 2009 , vol. 50, # 49 p. 6748 - 6750
反应条件
novozyme 435; sodium hydrogencarbonate in water T=50°C; pH=6.5 - 8.5; 24 h;
参考文献
Stuermer; Schaefer; Wolfart; Stahr; Kazmaier; Helmchen
Synthesis, 2001 , # 1 p. 46 - 48
反应条件
2-methoxy-ethanol; sodium hydride in ethylene glycol dimethyl ether T=0 - 20°C; 12 h;
参考文献
Lange, Udo E.W.; Baucke, Dorit; Hornberger, Wilfried; Mack, Helmut; Seitz, Werner; Hoeffken, H. Wolfgang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2648 - 2653
反应条件
triethylamine in tetrahydrofuran; methanol; water 2 h;
参考文献
Sibi, Mukund P.; Christensen, James W.
Tetrahedron Letters, 1995 , vol. 36, # 35 p. 6213 - 6216
反应条件
1: 93 percent / cyclohexane 2: 98 percent / Cl2Ru(PCy3)2CHMe / CH2Cl2 3: 87 percent / LDA / tetrahydrofuran / 0 °C 4: 45 percent / aq. NaHCO3; Novozym(R) View Scheme
参考文献
Stuermer; Schaefer; Wolfart; Stahr; Kazmaier; Helmchen
Synthesis, 2001 , # 1 p. 46 - 48
反应条件
1: 98 percent / Cl2Ru(PCy3)2CHMe / CH2Cl2 2: 87 percent / LDA / tetrahydrofuran / 0 °C 3: 45 percent / aq. NaHCO3; Novozym(R) View Scheme
参考文献
Stuermer; Schaefer; Wolfart; Stahr; Kazmaier; Helmchen
Synthesis, 2001 , # 1 p. 46 - 48
反应条件
2-(2-dimethylaminoethoxy)ethanol, sodium salt in toluene; acetonitrile T=20°C; 20 h;
参考文献
Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
Synthesis, 2004 , # 14 p. 2367 - 2375
反应条件
1: 87 percent / LDA / tetrahydrofuran / 0 °C 2: 45 percent / aq. NaHCO3; Novozym(R) View Scheme
参考文献
Stuermer; Schaefer; Wolfart; Stahr; Kazmaier; Helmchen
Synthesis, 2001 , # 1 p. 46 - 48
反应条件
Novozym(R); sodium hydrogencarbonate
参考文献
Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
Synthesis, 2004 , # 14 p. 2367 - 2375
