7-苯甲酰基-1,3-二氢吲哚-2-酮合成路线 （共 8 条）
反应条件
nickel in tetrahydrofuran 0.166667 h;
参考文献
Walsh; Moran; Shamblee; Uwaydah; Welstead Jr.; Sancilio; Dannenburg
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1379 - 1388
反应条件
1: tert-butyl hypochlorite / CH2Cl2 / 1 h / -70 °C 2: Et3N / CH2Cl2 / -70 - 20 °C 3: 3N aq. HCl / CH2Cl2 / 2 h / Heating 4: 94 percent / Raney nickel / tetrahydrofuran / 0.17 h View Scheme
参考文献
Walsh; Moran; Shamblee; Uwaydah; Welstead Jr.; Sancilio; Dannenburg
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1379 - 1388
反应条件
sodium cyanoborohydride; acetic acid in water; acetonitrile 6 h;
参考文献
Walsh, David A.; Shamblee, Dwight A.; Welstead, William J.; Sancilio, Lawrence F.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 446 - 451
反应条件
1: 80 percent / BCl3, AlCl3 / toluene / 16 h / Heating 2: MnO2 / CH2Cl2 / 18 h / Heating 3: N-chlorosuccinimide / CH2Cl2 / 1 h / 15 - 20 °C 4: 70percent aq. H3PO4 / 2-methoxy-ethanol / 8 h / Heating View Scheme
参考文献
Lo; Walsh; Welstead Jr.; et al.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 8 p. 1663 - 1664
反应条件
1: 80 percent / BCl3, AlCl3 / toluene / 16 h / Heating 2: MnO2 / CH2Cl2 / 18 h / Heating 3: N-chlorosuccinimide / CH2Cl2 / 1 h / 15 - 20 °C 4: 70percent aq. H3PO4 / 2-methoxy-ethanol / 8 h / Heating View Scheme
参考文献
Lo; Walsh; Welstead Jr.; et al.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 8 p. 1663 - 1664
反应条件
hydrogenchloride; formaldehyd; sodium cyanoborohydride; acetic acid 1.) acetonitrile, water, 6 h, 2.) 95percent aq. ethanol, reflux, 0.5 h; Multistep reaction;
参考文献
Walsh, David A.; Shamblee, Dwight A.; Welstead, William J.; Sancilio, Lawrence F.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 446 - 451
反应条件
sodium hydroxide in ethanol; toluene 5 h; Heating;
参考文献
Lo; Walsh; Welstead Jr.; et al.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 8 p. 1663 - 1664
参考文献
A. H. Robins Company, Incorporated
Patent: US4045576 A1, 1977 ;
