5,11-二甲基-6H-吡啶并[4,3-b]咔唑-9-醇合成路线 （共 10 条）
反应条件
ethylenediaminetetraacetic acid; oxygen; sodium carbonate 0.5 h; Ambient temperaturegeneration rates; var. pH; effect of var. ions; other hydroxyellipticine deriv.; Product distributionMechanism;
参考文献
Auclair, Christian; Hyland, Keith; Paoletti, Claude
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1438 - 1444
反应条件
pyridine hydrochloride
T=200 - 210°C; 0.666667 h;
参考文献
Anderson, Wayne K.; Gopalsamy, Ariamala; Reddy, Peech S.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1955 - 1963
反应条件
sulfuric acid; dihydrogen peroxide in methanol
4 h; Heating;
参考文献
Plug; Koomen; Pandit
Synthesis, 1992 , # 12 p. 1221 - 1222
反应条件
ascorbic acid powder in ethanol
参考文献
Pautet; Formisyn; Bourgois
Archiv der Pharmazie, 1993 , vol. 326, # 8 p. 499 - 500
反应条件
1: 97 percent / trifluoroacetic acid / 0.33 h / Heating
2: 91 percent / H2O2, 96percent H2SO4 / methanol / 4 h / Heating
View Scheme
参考文献
Plug; Koomen; Pandit
Synthesis, 1992 , # 12 p. 1221 - 1222
反应条件
D-glucose 6-Phosphate Dehydrogenase; Glc 6P; cytochrome b5; human cytochrome P450 3A4; NADP in methanol
T=37°C; pH=7.4; 0.333333 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Stiborova, Marie; Indra, Radek; Moserova, Michaela; Cerna, Vera; Rupertova, Martina; Martinek, Vaclav; Eckschlager, Tomas; Kizek, Rene; Frei, Eva
Chemical Research in Toxicology, 2012 , vol. 25, # 5 p. 1075 - 1085
参考文献
Formysin; Bourgois
Pharmazie, 1993 , vol. 48, # 5 p. 352 - 355
反应条件
air
other educt, also reaction under N2; decomposition reactions; Mechanism;
参考文献
Formysin; Bourgois
Pharmazie, 1993 , vol. 48, # 5 p. 352 - 355
反应条件
dihydrogen peroxide
T=25°C; 0.5 h; human myeloperoxidase (MPO); pH 7.80;
参考文献
Auclair; Paoletti
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 289 - 295
反应条件
ethylenediaminetetraacetic acid; oxygen; sodium carbonate
0.5 h; Ambient temperaturegeneration rates; var. pH; effect of var. ions; other hydroxyellipticine deriv.; Product distributionMechanism;
参考文献
Auclair, Christian; Hyland, Keith; Paoletti, Claude
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1438 - 1444
