4-(2-氨基-2-甲基丙基)苯胺合成路线 （共 11 条）
反应条件
hypodiphosphonic acid; sodium nitrite
参考文献
Kornblum; Iffland
Journal of the American Chemical Society, 1949 , vol. 71, p. 2137,2138,2140
反应条件
hydrogen; palladium 10 on activated carbon in methanol
P=760.051 Torr;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/52078 A1, 2009 ;
Location in patent: Page/Page column 79 ;
WO 2009/052078 A1
反应条件
hydrogen; 10 palladium on activated carbon in methanol
P=760.051 Torr; 6 h;
参考文献
Theravance, Inc.
Patent: US2005/159448 A1, 2005 ;
Location in patent: Page/Page column 19 ;
US 20050159448 A1
反应条件
sodium tetrahydroborate; copper diacetate in methanol; diethyl ether
Ambient temperature;
参考文献
Cowan, J. A.
Tetrahedron Letters, 1986 , vol. 27, # 10 p. 1205 - 1208
反应条件
sodium hydroxide; nickel; hydrazine in ethanol
T=40°C; 0.333333 h;
参考文献
Milecki, Jan; Baker, Stephen P.; Standifer, Kelly M.; Ishizu, Takashi; Chida, Yasuhiro; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1563 - 1566
反应条件
in 1,4-dioxane; ruthenium
参考文献
Allied Chemical Corporation
Patent: US4024185 A1, 1977 ;
反应条件
1: 56 percent / conc. H2SO4, 70percent aq. HNO3 / 0.33 h
2: 3.87 g / NaOH, hydrazine, Raney nickel / ethanol / 0.33 h / 40 °C
View Scheme
参考文献
Milecki, Jan; Baker, Stephen P.; Standifer, Kelly M.; Ishizu, Takashi; Chida, Yasuhiro; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1563 - 1566
反应条件
1: sulfuric acid; nitric acid / -10 °C
2: sodium hydroxide
View Scheme
参考文献
Jacobsen, John R.; Choi, Seok Ki; Combs, Jesse; Fournier, Eric J.L.; Klein, Uwe; Pfeiffer, Juergen W.; Thomas, G. Roger; Yu, Cecile; Moran, Edmund J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1213 - 1218
反应条件
thallium(III) chloride; sodium iodide in water
1 h; HeatingpH 4.0;
参考文献
Rashidbaigi; Ruoho
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 3 p. 305 - 307
反应条件
sodium iodide; sodium nitrite in water
参考文献
University of Florida
Patent: US4894219 A1, 1990 ;
US 4894219 A
