(S)-N-甲基-1-[3,5-二(三氟甲基)苯基]乙胺合成路线 （共 11 条）
反应条件
water; hydrogen; palladium on activated charcoal in methanol T=60°C; P=3750.3 Torr; 12 h;
参考文献
Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro
Organic Letters, 2003 , vol. 5, # 7 p. 1007 - 1010
反应条件
1: With (+)-(R)-malic acid in ethyl acetate T=0°C; 5.83333 h; Resolution of racemate; 2: With sodium hydroxide in water
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/110996 A1, 2004 ;
Location in patent: Page/Page column 25 ;
WO 2004/110996 A1
反应条件
hydrogenchloride in methanol 0.25 h; Inert atmosphere;
参考文献
LEO PHARMA A/S; SØRENSEN, Morten, Dahl; DI FABIO, Romani; POZZAN, Alfonso; CATALANI, Maria, Pia; BLADH, Haakon; FELDING, Jakob
Patent: WO2013/124286 A1, 2013 ;
Location in patent: Page/Page column 126; 127 ;
反应条件
C23H25N3O2; trichlorosilane in ethyl acetate T=0°C; 5 h; Overall yield = 93 percent; Overall yield = 5.06 g;
参考文献
THE UNIVERSITY OF SHEFFIELD; JONES, Simon; LI, Xianfu
Patent: WO2013/79942 A1, 2013 ;
Location in patent: Page/Page column 29; 30 ;
反应条件
in water; toluene T=50°C; P=1350.14 Torr; 48 h;
参考文献
AVECIA PHARMACEUTICALS LIMITED
Patent: WO2006/67395 A1, 2006 ;
Location in patent: Page/Page column 22-23 ;
反应条件
1: zinc chloride / toluene / 15 h / Heating 2: sodium borohydride / methanol / 12 h / 0 °C 3: potassium carbonate / dimethylformamide / 24 h / 20 °C 4: 100 percent / hydrogen; water / 5 percent Pd/C NX-type / methanol / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro
Organic Letters, 2003 , vol. 5, # 7 p. 1007 - 1010
反应条件
1: sodium borohydride / methanol / 12 h / 0 °C 2: potassium carbonate / dimethylformamide / 24 h / 20 °C 3: 100 percent / hydrogen; water / 5 percent Pd/C NX-type / methanol / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro
Organic Letters, 2003 , vol. 5, # 7 p. 1007 - 1010
反应条件
1: potassium carbonate / dimethylformamide / 24 h / 20 °C 2: 100 percent / hydrogen; water / 5 percent Pd/C NX-type / methanol / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro
Organic Letters, 2003 , vol. 5, # 7 p. 1007 - 1010
反应条件
1.1: titanium(IV) isopropylate / dichloromethane / 20 h / 0 - 20 °C / |Inert atmosphere 2.1: dichloromethane; tetrahydrofuran / 5 h / -60 - 20 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / |Inert atmosphere 3.2: 3 h / -60 - 20 °C 4.1: hydrogenchloride / methanol / 0.25 h / |Inert atmosphere View Scheme
参考文献
LEO PHARMA A/S; SØRENSEN, Morten, Dahl; DI FABIO, Romani; POZZAN, Alfonso; CATALANI, Maria, Pia; BLADH, Haakon; FELDING, Jakob
Patent: WO2013/124286 A1, 2013 ;
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / |Inert atmosphere 1.2: 3 h / -60 - 20 °C 2.1: hydrogenchloride / methanol / 0.25 h / |Inert atmosphere View Scheme
参考文献
LEO PHARMA A/S; SØRENSEN, Morten, Dahl; DI FABIO, Romani; POZZAN, Alfonso; CATALANI, Maria, Pia; BLADH, Haakon; FELDING, Jakob
Patent: WO2013/124286 A1, 2013 ;
