1: benzophenone With 1,2-disodiostilbene in tetrahydrofuran T=0°C; Inert atmosphere; 2: N-(2-chloroethyl)-piperidine in tetrahydrofuran; diethyl ether T=0°C; Inert atmosphere; 3: With water in tetrahydrofuran; diethyl ether T=0°C; Inert atmosphere;

diethyl ether

1.1: Mg / tetrahydrofuran / 1 h / Heating 1.2: 81 percent / tetrahydrofuran / 0 °C 2.1: tetrahydrofuran / 2.5 h / 0 °C View Scheme

diethyl ether

diethyl ether

acetic acid; platinum Hydrogenation;

phosphoric acid T=140°C;