ammonium hydroxide in 1,4-dioxane 48 h; Ambient temperature;

1: POCl3, Et3N / acetonitrile / 16 h / Ambient temperature 2: 72 percent / conc. NH4OH / dioxane / 48 h / Ambient temperature View Scheme

1: 85.7 percent / pyridine; dimethylformamide / 3 h / Ambient temperature 2: POCl3, Et3N / acetonitrile / 16 h / Ambient temperature 3: 72 percent / conc. NH4OH / dioxane / 48 h / Ambient temperature View Scheme