19-羟基-4-雄甾烯-3,17-二酮合成路线 （共 36 条）
反应条件
oxygen; NADPH T=37°C; 0.333333 h; D-, 18-O-labelled; Mechanism;
参考文献
Akhtar, Muhammed; Calder, Michael R.; Corina, David L.; Wright, J. Neville
Journal of the Chemical Society, Chemical Communications, 1981 , # 3 p. 129 - 130
反应条件
1: 7.3 g / Cr2O3, conc. H2SO4 / acetone / 0.5 h / 10 - 15 °C 2: 700 mg / pyridine / 1 h / 50 °C 3: 2.55 g / TsOH / benzene / 2 h / Heating 4: 1.) tBuOK, 2.) TsOH / 1.) Et2O, -30 deg C, 24 h, 2.) acetone, TsOH, 2 h View Scheme
参考文献
Templeton, John F.; Ling, Yangzhi; Lin, Weiyang; Pitura, Randy J.; Marat, Kirk; Bridson, John N.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 9 p. 1149 - 1158
反应条件
1: 48 percent / Jones reagent / acetone 2: 89 percent / diethyl ether View Scheme
参考文献
Templeton, John F.; Majgier-Baranowska, Helena; Marat, Kirk
Steroids, 2000 , vol. 65, # 4 p. 219 - 223
反应条件
1: 97 percent / PPTS / tetrahydrofuran / 15 h / Ambient temperature
2: 1.) Li, NH3, 2.) NH4Cl / 1.) THF, -78 deg C, 5 min, 2.) -78 deg C -> room temperature, 1 h
3: PTSA / tetrahydrofuran / 4.5 h
View Scheme
参考文献
Oh, Soonsin S.; Robinson, Cecil H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 16 p. 2237 - 2244
反应条件
1: pyridinium p-toluenesulfonate / tetrahydrofuran / 20 h / 20 °C / |Inert atmosphere
2: lithium; ammonia / tetrahydrofuran; hexane / -78 °C
3: toluene-4-sulfonic acid / methanol; dichloromethane / 10 h / 23 °C
View Scheme
参考文献
Cheng, Qian; Sohl, Christal D.; Yoshimoto, Francis K.; Guengerich, F. Peter
Journal of Biological Chemistry, 2012 , vol. 287, # 35 p. 29554 - 29567,14
Title/Abstract Full Text Show Details
Cheng, Qian; Sohl, Christal D.; Yoshimoto, Francis K.; Guengerich, F. Peter
Journal of Biological Chemistry, 2012 , vol. 287, # 35 p. 29554 - 29567
反应条件
oxygen; NADPH
T=37°C; 0.333333 h; D-, 18-O-labelled; Mechanism;
参考文献
Akhtar, Muhammed; Calder, Michael R.; Corina, David L.; Wright, J. Neville
Journal of the Chemical Society, Chemical Communications, 1981 , # 3 p. 129 - 130
