4-(4-氯苯基)-1H-1,2,4-三唑-5(4H)-酮合成路线 （共 3 条）
反应条件
acetic acid in N,N-dimethyl-formamide T=80°C; 8 h;
参考文献
Sheng, Chunquan; Che, Xiaoying; Wang, Wenya; Wang, Shengzheng; Cao, Yongbing; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5276 - 5282
反应条件
sodium methylate; trimethyl orthoformate in methanol; water
参考文献
Wyckoff Chemical Company, Inc.
Patent: US5728834 A1, 1998 ;
反应条件
1: in methanol 2 h; Reflux; 2: With sodium methylate in methanol 3 h; Reflux; 3: With hydrogenchloride in water pH=1;
参考文献
Jiang, Yongwei; Cao, Yongbin; Zhang, Jun; Zou, Yan; Chai, Xiaoyun; Hu, Honggang; Zhao, Qingjie; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Sun, Qingyan
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3135 - 3141
