8-氯-5,10-二氢-11H-二苯并[b,e][1,4]二氮杂卓-11-酮合成路线 （共 18 条）
参考文献
Sasikumar; Burnett; Zhang; Smith-Torhan; Fawzi; Lachowicz
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4543 - 4547
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20 - 150°C; 6 h; Inert atmosphere;
参考文献
Li, Yanqiu; Zhan, Chunjing; Yang, Bingchuan; Cao, Xiaoqun; Ma, Chen
Synthesis (Germany), 2013 , vol. 45, # 1 art. no. SS-2012-H0697-OP, p. 111 - 117
反应条件
1: 64 percent / Na2S2O4 / aq. NH3 / 80 °C 2: 79 percent / xylene / 96 h / Heating View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: K2CO3 / dimethylformamide / 140 °C 2: 90 percent / DVP-Fe, conc. HCl / aq. ethanol; H2O / Heating 3: conc. H3PO4 / xylene / 140 °C View Scheme
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
反应条件
1: K2CO3 / dimethylformamide / 140 °C 2: 90 percent / DVP-Fe, conc. HCl / aq. ethanol; H2O / Heating 3: conc. H3PO4 / xylene / 140 °C View Scheme
参考文献
Ruger; Rohnert; Lohmann
Pharmazie, 1990 , vol. 45, # 8 p. 555 - 559
反应条件
1: 74 percent / K2CO3; Cu / various solvent(s) / 4 h / Heating 2: 64 percent / Na2S2O4 / aq. NH3 / 80 °C 3: 79 percent / xylene / 96 h / Heating View Scheme
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
反应条件
1: hydrogenchloride / water / 2 h / |Reflux 2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 3: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux 4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(N,N-dimethlyamino)pyridine / acetonitrile / |Microwave irradiation View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 2: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux 3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(N,N-dimethlyamino)pyridine / acetonitrile / |Microwave irradiation View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: nitric acid; sulfuric acid / 2 h / 70 °C 2: potassium permanganate; water / 8 h / |Reflux 3: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C 4: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C 5: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 6: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux 7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(N,N-dimethlyamino)pyridine / acetonitrile / |Microwave irradiation View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: potassium permanganate; water / 8 h / |Reflux 2: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C 3: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C 4: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 5: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux 6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(N,N-dimethlyamino)pyridine / acetonitrile / |Microwave irradiation View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
