(5-羧基戊基)三苯基溴化磷合成路线 （共 27 条）
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -10 deg C, 45 min, 2.) THF, hexane, room temperature, overnight 2: 86 percent / H2 / Pd/C / methanol / 6 h View Scheme
参考文献
Deshmukh; Veeresh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 12 p. 1239 - 1241
反应条件
1: t-BuOK / dimethylformamide / 15 h / Ambient temperature 2: thionyl chloride / 1.) RT, 8 h, 2.) 100 deg C, 0.5 h 3: diethyl ether / 1.) room temp., 2 h, 2.) reflux, 2 h View Scheme
参考文献
Kaga, Harumi; Miura, Masakatsu; Orito, Kazuhiko
Journal of Organic Chemistry, 1989 , vol. 54, p. 3477 - 3478
反应条件
1: 1.) t-BuOK / 1.) THF, 0 deg C, 20 min, 2.) THF, RT 2: H2 / 10percent Pd/C / 2942.03 Torr 3: 1.) Et3N / 1.) CH2Cl2, 0 deg C, 15 min, 2.) CH2Cl2, 30 min 4: CH2Cl2 / 1 h View Scheme
参考文献
Kiuchi, Fumiyuki; Nakamura, Norio; Saito, Makiko; Komagome, Kazue; Hiramatsu, Hirokuni; Takimoto, Noriaki; Akao, Nobuaki; Kondo, Kaoru; Tsuda, Yoshisuke
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 4 p. 685 - 696
反应条件
1: 1.) t-BuOK / 1.) THF, 0 deg C, 20 min, 2.) THF, 50 min, RT
2: H2 / Pd/C / ethanol
View Scheme
参考文献
Kiuchi, Fumiyuki; Nakamura, Norio; Saito, Makiko; Komagome, Kazue; Hiramatsu, Hirokuni; Takimoto, Noriaki; Akao, Nobuaki; Kondo, Kaoru; Tsuda, Yoshisuke
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 4 p. 685 - 696
反应条件
1.1: NaHMDS; HMPA / tetrahydrofuran / 1 h / -30 °C
1.2: 38 percent / tetrahydrofuran / -30 - 20 °C
2.1: 60 percent / Li; liq. NH3 / tetrahydrofuran / 2 h / cooling
View Scheme
参考文献
Nanda; Yadav
Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1799 - 1806
反应条件
n-butyllithium in tetrahydrofuran
参考文献
Nikken Chemicals Company, Limited
Patent: EP807626 A1, 1997 ;
反应条件
sodium hydride
1.) DMSO, RT, 10 min, 2.) DMSO, RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kato, Kaneyoshi; Ohkawa, Shigenori; Terao, Shinji; Terashita, Zen-ichi; Nishikawa, Kohei
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 287 - 294
反应条件
sodium hydride
1.) DMSO, RT, 10 min, 2.) DMSO, RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kato, Kaneyoshi; Ohkawa, Shigenori; Terao, Shinji; Terashita, Zen-ichi; Nishikawa, Kohei
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 287 - 294
反应条件
sodium hydride
1.) DMSO, RT, 10 min, 2.) DMSO, RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kato, Kaneyoshi; Ohkawa, Shigenori; Terao, Shinji; Terashita, Zen-ichi; Nishikawa, Kohei
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 287 - 294
反应条件
sodium hydride
1.) DMSO, RT, 10 min, 2.) DMSO, RT; Yield given. Multistep reaction;
参考文献
Kato, Kaneyoshi; Ohkawa, Shigenori; Terao, Shinji; Terashita, Zen-ichi; Nishikawa, Kohei
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 287 - 294
