7-氯甲基氧基-羰基氧基-6-(5-氯吡啶-2-基)-6,7-二氢-5H-吡咯并[3,4-b]吡嗪-5-酮合成路线 （共 4 条）
反应条件
pyridine in dichloromethane T=20°C; 17 h;
参考文献
Universidad de Oviedo; Astur Pharma, S.A.
Patent: US6969767 B1, 2005 ;
Location in patent: Page/Page column 8; 9 ;
反应条件
propan-1-ol; triethylamine; Novozymereg; 435 in toluene T=45°C; 16 - 24 h; Enzymatic reactionResolution of racemate; Purification / work up;
参考文献
Apotecnia , S.A.
Patent: EP2058313 A2, 2009 ;
Location in patent: Page/Page column 9 ;
反应条件
phosphate buffer; Candida antarctica lipase B Chirazyme-L2; triethylamine in water; toluene T=60°C; pH=7; 96 h;
参考文献
Solares, Laura F.; Diaz, Monica; Brieva, Rosario; Sanchez, Victor M.; Bayod, Miguel; Gotor, Vicente
Tetrahedron Asymmetry, 2002 , vol. 13, # 23 p. 2577 - 2582
反应条件
1: Candida antarctica lipase B Chirazyme-L2; phosphate buffer; triethylamine / toluene; H2O / 96 h / 60 °C / pH 7 2: 90 percent / acetone / 0 - 20 °C View Scheme
参考文献
Solares, Laura F.; Diaz, Monica; Brieva, Rosario; Sanchez, Victor M.; Bayod, Miguel; Gotor, Vicente
Tetrahedron Asymmetry, 2002 , vol. 13, # 23 p. 2577 - 2582
