3-甲氧基-4-硝基苯甲酸合成路线 （共 45 条）
反应条件
sulfuric acid; nitric acid; acetic anhydride T=-10 - -5°C;
参考文献
Froelicher; Cohen
Journal of the Chemical Society, 1921 , vol. 119, p. 1431
参考文献
Rieche
Chemische Berichte, 1889 , vol. 22, p. 2354
反应条件
potassium permanganate; sodium carbonate
参考文献
Rieche
Chemische Berichte, 1889 , vol. 22, p. 2354
反应条件
1: nitric acid / 0 - 10 °C / Aus Benzol krystallisiert 2-Nitro-3-methoxy-benzaldehyd aus; die beiden anderen Isomeren koennen nach Entfernung des Benzols durch Destillation mit Wasserdampf getrennt werden 2: silver oxide View Scheme
参考文献
Rieche
Chemische Berichte, 1889 , vol. 22, p. 2354
参考文献
Simonsen; Rau
Journal of the Chemical Society, 1917 , vol. 111, p. 232
参考文献
Froelicher; Cohen
Journal of the Chemical Society, 1921 , vol. 119, p. 1431
反应条件
thionyl chloride T=0 - 20°C;
参考文献
PORTOLA PHARMACEUTICALS, INC.
Patent: WO2005/32488 A2, 2005 ;
Location in patent: Page/Page column 52 ;
反应条件
thionyl chloride in methanol
参考文献
Mitsui Chemicals, Inc.
Patent: US5852011 A1, 1998 ;
反应条件
1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C 2: hydrogen / Raney nickel / methanol / 16 h / 20 °C View Scheme
参考文献
ABBVIE INC.; Vasudevan, Anil; Penning, Thomas Dale; Chen, Huanming; Liang, Bo; Wang, Shaohui; Zhao, Zhongqiang; Chai, Dikun; Yang, Leifu; Gao, Yingxiang; Pliushchev, Marina
Patent: US2014/171429 A1, 2014 ;
反应条件
1: 91 percent / BF3 / 12 h 2: 91 percent / hydrogen / 10percent Pd/C / CH2Cl2; ethanol / 12 h View Scheme
参考文献
Mok, N. Yi; Chadwick, James; Kellett, Katherine A. B.; Casas-Arce, Eva; Hooper, Nigel M.; Johnson, A. Peter; Fishwick, Colin W. G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 5 p. 1843 - 1852
