3-甲氧基-4-硝基苯甲酸合成路线 （共 45 条）
反应条件
1: methanol With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: 3-fluoro-4-nitro benzoic acid methylester in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
DEVELOGEN AKTIENGESELLSCHAFT
Patent: WO2006/136402 A1, 2006 ;
Location in patent: Page/Page column 119 ;
WO 2006/136402 A1
反应条件
1: methanol With sodium methylate in tetrahydrofuran T=0°C; 0.25 h; Inert atmosphere; 2: 3-fluoro-4-nitro-benzoic acid in tetrahydrofuran T=0 - 25°C; 1 h; Inert atmosphere;
参考文献
Shaginian, Alex; Whitby, Landon R.; Hong, Sukwon; Hwang, Inkyu; Farooqi, Bilal; et al.
Journal of the American Chemical Society, 2009 , vol. 131, p. 5564 - 5572
反应条件
potassium permanganate; sodium carbonate in water 1.5 h; Heating;
参考文献
Ismail, Ibrahim A.; Sharp, Dale E.; Chedekel, Miles R.
Journal of Organic Chemistry, 1980 , vol. 45, # 11 p. 2243 - 2246
反应条件
sodium hydroxide in methanol 0.5 h; Yield given;
参考文献
Adams, S. R.; Kao, J. P. Y.; Tsien, R. Y.
Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 7957 - 7968
参考文献
Schmelkes; Rubin
Journal of the American Chemical Society, 1944 , vol. 66, p. 1631
反应条件
T=85°C; Hofmann rearrangement;
参考文献
Shine, Henry J.; Park, Koon Ha; Brownawell, Marilyn L.; Filippo, Joseph San
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7077 - 7082
反应条件
1: aqueous potassium permanganate solution 2: methanol. KOH-solution View Scheme
参考文献
Schmelkes; Rubin
Journal of the American Chemical Society, 1944 , vol. 66, p. 1631
反应条件
1: 90 percent / aq. NaOH / H2O / 80 °C 2: 100 percent / KMnO4, Na2CO3 / H2O / 1.5 h / Heating View Scheme
参考文献
Ismail, Ibrahim A.; Sharp, Dale E.; Chedekel, Miles R.
Journal of Organic Chemistry, 1980 , vol. 45, # 11 p. 2243 - 2246
反应条件
2: 5 g / 85 °C / Hofmann rearrangement View Scheme
参考文献
Shine, Henry J.; Park, Koon Ha; Brownawell, Marilyn L.; Filippo, Joseph San
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7077 - 7082
反应条件
potassium carbonate; N,N-dimethyl-formamide T=140°C;
参考文献
Shen, Bin; Loeffler, Dirk; Zeller, Klaus-Peter; Uebele, Michael; Reischl, Gerald; Machulla, Hans-Juergen
Journal of Fluorine Chemistry, 2007 , vol. 128, # 12 p. 1461 - 1468
