2-甲基-4-硝基苯甲醚合成路线 （共 35 条）
反应条件
potassium carbonate in acetonitrile T=80°C; 12 h;
参考文献
AKZO NOBEL N.V.; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2006/95014 A1, 2006 ;
Location in patent: Page/Page column 33 ;
WO 2006/095014 A1
反应条件
diethylzinc; tetrakis(triphenylphosphine) palladium(0) in hexane; N,N-dimethyl-formamide T=25°C; 1 h;
参考文献
Agrios, Konstantinos A.; Srebnik, Morris
Journal of Organic Chemistry, 1993 , vol. 58, # 24 p. 6908 - 6910
反应条件
potassium carbonate; xylene
参考文献
JAMES BLACK FOUNDATION
Patent: WO2007/135417 A1, 2007 ;
Location in patent: Page/Page column 63 ;
WO 2007/135417 A1
反应条件
nitric acid T=-10°C; 2 h;
参考文献
Knolker; Bauermeister; Pannek; Wolpert
Synthesis, 1995 , # 4 p. 397 - 408
反应条件
TNM in acetonitrile T=25°C; Irradiation; Title compound not separated from byproducts;
参考文献
Sankararaman,S.; Haney,W.A.; Kochi,J.K.
Journal of the American Chemical Society, 1987 , vol. 109, p. 7824
反应条件
sodium methylate in diethyl ether; N,N-dimethyl-formamide
参考文献
Schiemann
Chemische Berichte, 1929 , vol. 62, p. 1804
反应条件
1: methanol With N-benzyl-trimethylammonium hydroxide 0.166667 h; Neat (no solvent); 2: 1-Fluoro-2-methyl-4-nitrobenzene T=20°C; 0.25 h; Neat (no solvent);
参考文献
Meshram; Goud, P. Ramesh; Reddy, B. Chennakesava; Kumar, D. Aravind
Synthetic Communications, 2010 , vol. 40, # 14 p. 2122 - 2129
反应条件
1: methanol With N-benzyl-trimethylammonium hydroxide 0.166667 h; Neat (no solvent); 2: 1-chloro-2-methyl-4-nitrobenzene T=20°C; 0.25 h; Neat (no solvent);
参考文献
Meshram; Goud, P. Ramesh; Reddy, B. Chennakesava; Kumar, D. Aravind
Synthetic Communications, 2010 , vol. 40, # 14 p. 2122 - 2129
反应条件
in dichloromethane 15 h; Irradiation; Product distribution;
参考文献
Sankararaman, S.; Kochi, J. K.
Recueil des Travaux Chimiques des Pays-Bas, 1986 , vol. 105, p. 278 - 285
反应条件
nitric acid T=-10°C; 2 h;
参考文献
Nafissi-V, Mehdi M.; Koharski, David P.; Puar, Mohindar S.; McPhail, Andrew T.
Journal of Organic Chemistry, 1982 , vol. 47, # 17 p. 3345 - 3348
