5-氯甲基-3-(4-甲基苯基)-1,2,4-噁二唑合成路线 （共 6 条）
反应条件
in toluene 2 h; RefluxMolecular sieve;
参考文献
Ozcan, Sevil; Kazi, Aslamuzzaman; Marsilio, Frank; Fang, Bin; Guida, Wayne C.; Koomen, John; Lawrence, Harshani R.; Sebti, Said M.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 3783 - 3805
反应条件
triethylamine in benzene 10 h; Reflux;
参考文献
Dueruest, Yaar; Karaku, Hamza; Kaiser, Marcel; Tasdemir, Deniz
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 296 - 304
反应条件
1: NH2OH*HCl; Et3N / ethanol / Heating 2: DIEA / 1,2-dichloro-ethane / Heating View Scheme
参考文献
Dueruest, Yaar; Karaku, Hamza; Kaiser, Marcel; Tasdemir, Deniz
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 296 - 304
反应条件
1: DIEA / CH2Cl2 / 24 h / 20 °C 2: toluene / 24 h / Heating View Scheme
参考文献
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; LAWRENCE, Harshani R.; SEBTI, Said M.; OZCAN, Sevil
Patent: WO2012/129564 A2, 2012 ;
WO 2012/129564 A2
反应条件
1: potassium carbonate / acetonitrile / 1 h / Reflux
2: hydrazine / ethanol / 0.5 h / Reflux
View Scheme
参考文献
Ozcan, Sevil; Kazi, Aslamuzzaman; Marsilio, Frank; Fang, Bin; Guida, Wayne C.; Koomen, John; Lawrence, Harshani R.; Sebti, Said M.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 3783 - 3805
反应条件
potassium carbonate in acetonitrile
0.5 h; Reflux;
参考文献
Ozcan, Sevil; Kazi, Aslamuzzaman; Marsilio, Frank; Fang, Bin; Guida, Wayne C.; Koomen, John; Lawrence, Harshani R.; Sebti, Said M.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 3783 - 3805
