5-甲氧基异吲哚烷-1,3-二酮合成路线 （共 11 条）
反应条件
hydrogenchloride; tin in ethanol 12 h; Heating;
参考文献
Hennige, Hans; Kreher, Richard P.; Konrad, Michael; Jelitto, Frank
Chemische Berichte, 1988 , vol. 121, p. 243 - 252
反应条件
1: With borane-THF in tetrahydrofuran T=0°C; 16 h; Heating / reflux; 2: With hydrogenchloride in tetrahydrofuran; methanol; water 3 h; Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44045 A1, 2008 ;
Location in patent: Page/Page column 277-279 ;
WO 2008/044045 A1
反应条件
formamide
T=210°C; 5 h;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44045 A1, 2008 ;
Location in patent: Page/Page column 277-278 ;
WO 2008/044045 A1
反应条件
acetic anhydride; urea
1) reflux, 24h, 2) xylene, reflux, 20h; Multistep reaction;
参考文献
Mazzocchi, P. H.; Wilson, P.; Khachik, F.; Klingler, L.; Minamikawa, S.
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 2981 - 2989
反应条件
1: 53 percent / K2CO3 / 2 h / 90 °C
2: 0.25 h / 170 °C
3: 60 percent / formamide / 2.5 h / Heating
View Scheme
参考文献
Hennige, Hans; Kreher, Richard P.; Konrad, Michael; Jelitto, Frank
Chemische Berichte, 1988 , vol. 121, p. 243 - 252
反应条件
1: 2.8 g / 11 N NaOH / acetone / 25 °C
2: 1) acetic anhydride, 2) urea / 1) reflux, 24h, 2) xylene, reflux, 20h
View Scheme
参考文献
Mazzocchi, P. H.; Wilson, P.; Khachik, F.; Klingler, L.; Minamikawa, S.
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 2981 - 2989
反应条件
1: 1) K2CO3 / 1) acetone, 50 degC, 1h, 2) reflux
2: 2.8 g / 11 N NaOH / acetone / 25 °C
3: 1) acetic anhydride, 2) urea / 1) reflux, 24h, 2) xylene, reflux, 20h
View Scheme
参考文献
Mazzocchi, P. H.; Wilson, P.; Khachik, F.; Klingler, L.; Minamikawa, S.
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 2981 - 2989
反应条件
1: H2SO4 (65 percent SO3) / 3 h / 200 °C
2: NaOH / 2.5 h / 175 °C
3: 53 percent / K2CO3 / 2 h / 90 °C
4: 0.25 h / 170 °C
5: 60 percent / formamide / 2.5 h / Heating
View Scheme
参考文献
Hennige, Hans; Kreher, Richard P.; Konrad, Michael; Jelitto, Frank
Chemische Berichte, 1988 , vol. 121, p. 243 - 252
反应条件
1: NaOH / 2.5 h / 175 °C
2: 53 percent / K2CO3 / 2 h / 90 °C
3: 0.25 h / 170 °C
4: 60 percent / formamide / 2.5 h / Heating
View Scheme
参考文献
Hennige, Hans; Kreher, Richard P.; Konrad, Michael; Jelitto, Frank
Chemische Berichte, 1988 , vol. 121, p. 243 - 252
参考文献
Helfer
Helvetica Chimica Acta, 1924 , vol. 7, p. 955
