2-(4-硝基苯基)丙腈合成路线 （共 12 条）
反应条件
2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine; L-proline in dimethyl sulfoxide T=25°C; 24 h;
参考文献
Ramachary, Dhevalapally B.; Shiva Prasad
Tetrahedron Letters, 2010 , vol. 51, # 40 p. 5246 - 5251
反应条件
sodium hydroxide in dimethyl sulfoxide 1 h; Ambient temperature;
参考文献
Makosza, Mieczyslaw; Winiarski, Jerzy
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1494 - 1499
反应条件
in α,α'-dimethoxydiethyl ether; water; tert-butyl alcohol
参考文献
ELI LILLY AND COMPANY
Patent: EP994110 A1, 2000 ;
反应条件
sodium hydroxide in dimethyl sulfoxide 1 h; Ambient temperature;
参考文献
Makosza, Mieczyslaw; Winiarski, Jerzy
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1494 - 1499
参考文献
Nannini; Giraldi; Molgora; Biasoli; Spinelli; Logemann; Dradi; Zanni; Buttinoni; Tommasini
Arzneimittel-Forschung/Drug Research, 1973 , vol. 23, # 8 p. 1090 - 1100
参考文献
Opolski; Kowalski; Pilewski
Chemische Berichte, 1916 , vol. 49, p. 2280
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran; ethanol T=20°C; P=1448.05 - 2430.66 Torr; 0.5 h;
参考文献
Gruenenthal GmbH
Patent: US2009/156590 A1, 2009 ;
Location in patent: Page/Page column 47; 72 ;
US 20090156590 A1
反应条件
1: aq. H2SO4 2: H2SO4 3: H2 / Pd-C / ethanol View Scheme
参考文献
Nannini; Giraldi; Molgora; Biasoli; Spinelli; Logemann; Dradi; Zanni; Buttinoni; Tommasini
Arzneimittel-Forschung/Drug Research, 1973 , vol. 23, # 8 p. 1090 - 1100
反应条件
hydrogenchloride in water T=20°C; 14 h; Heating / reflux; Product distribution / selectivity;
参考文献
Gruenenthal GmbH
Patent: US2009/156590 A1, 2009 ;
Location in patent: Page/Page column 62; 63; 64; 65 ;
US 20090156590 A1
参考文献
Opolski; Kowalski; Pilewski
Chemische Berichte, 1916 , vol. 49, p. 2280
