3-苯基吡唑-5-羧酸水合物合成路线 （共 12 条）
反应条件
lithium hydroxide hydrate in tetrahydrofuran; water T=20°C; 2 h;
参考文献
PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher
Patent: WO2014/20351 A1, 2014 ;
Location in patent: Page/Page column 36 ;
反应条件
water; sodium hydroxide in ethanol T=150°C; 2 h; Microwave irradiationSealed tube;
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
water; sodium hydroxide in ethanol T=120°C; 1 h; Microwave irradiationSealed tube;
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 18 h;
参考文献
Van Herk; Brussee; Van den Nieuwendijk; Van der Klein; IJzerman; Stannek; Burmeister; Lorenzen
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3945 - 3951
反应条件
1: EtONa / ethanol / 18 h / 20 °C 2: N2H4*H2O; AcOH / 8 h / Heating 3: 81 percent / aq. NaOH / dioxane / 18 h / 20 °C View Scheme
参考文献
Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan; Adil; Nayak, V. Lakshma; Ramakrishna
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 273 - 280
反应条件
1: N2H4*H2O; AcOH / 8 h / Heating 2: 81 percent / aq. NaOH / dioxane / 18 h / 20 °C View Scheme
参考文献
Van Herk; Brussee; Van den Nieuwendijk; Van der Klein; IJzerman; Stannek; Burmeister; Lorenzen
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3945 - 3951
反应条件
1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / water; propan-1-ol / 1 h / 110 °C / |Inert atmosphere; |Sealed tube; |Microwave irradiation 2: sodium hydroxide; water / ethanol / 2 h / 150 °C / |Microwave irradiation; |Sealed tube View Scheme
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
1.1: NH2NH2•xH2O / ethanol / |Reflux 1.2: 0.02 h / |Reflux 2.1: sodium hydroxide; water / ethanol / 1 h / 120 °C / |Microwave irradiation; |Sealed tube View Scheme
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
1: acetic acid; hydrazine hydrate / 1 h / |Reflux 2: hydroxylamine hydrochloride; sodium hydroxide / methanol / 1 h / 80 °C View Scheme
参考文献
Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan; Adil; Nayak, V. Lakshma; Ramakrishna
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 273 - 280
反应条件
sodium hydroxide; monohydrazine sulfate
参考文献
Knorr
Justus Liebigs Annalen der Chemie, 1894 , vol. 279, p. 253 Anm. 3
Chemische Berichte, 1895 , vol. 28, p. 697
Full Text Show Details
Wenglein
Dissertation <Jena 1895>,S.15
