O(6)-乙基-2'-脱氧鸟苷合成路线 （共 12 条）
反应条件
ammonium hydroxide
T=50°C; 72 h;
参考文献
Gaffney; Jones
Tetrahedron Letters, 1982 , vol. 23, # 22 p. 2253 - 2256
反应条件
trifluoroacetic acid in dichloromethane
0.166667 h;
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
1: CH2Cl2 / 0.17 h / 0 °C
2: 1.) DBU 2.) 1N NaOH / 0.17 h / 0 °C
3: 100 percent / NH4OH / 72 h / 50 °C
View Scheme
参考文献
Gaffney; Jones
Tetrahedron Letters, 1982 , vol. 23, # 22 p. 2253 - 2256
反应条件
1: 87 percent / Et3N, 4-dimethylaminopyridine / CH2Cl2 / 2 h / Ambient temperature
2: CH2Cl2 / 0.17 h / 0 °C
3: 1.) DBU 2.) 1N NaOH / 0.17 h / 0 °C
4: 100 percent / NH4OH / 72 h / 50 °C
View Scheme
参考文献
Gaffney; Jones
Tetrahedron Letters, 1982 , vol. 23, # 22 p. 2253 - 2256
反应条件
1: 37 percent / KOH, tris-<2-(2-methoxyethoxy)ethyl>amine / acetonitrile / 0.33 h / Ambient temperature
2: 79 percent / NaOMe / methanol / 0.5 h / Ambient temperature
View Scheme
参考文献
Seela, Frank; Leonard, Peter
Helvetica Chimica Acta, 1997 , vol. 80, # 4 p. 1301 - 1318
反应条件
1: 37 percent / KOH, tris-<2-(2-methoxyethoxy)ethyl>amine / acetonitrile / 0.33 h / Ambient temperature
2: 79 percent / NaOMe / methanol / 0.5 h / Ambient temperature
View Scheme
参考文献
Seela, Frank; Leonard, Peter
Helvetica Chimica Acta, 1997 , vol. 80, # 4 p. 1301 - 1318
反应条件
1: N-methylimidazole (NMI) / pyridine / 0.5 h / 20 °C
2: 81 percent / 4-(dimethylamino)pyridine (DMAP), triethylamine / CH2Cl2 / 16 h
3: 66 percent / N-methylpyrrolidine, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / CH2Cl2 / 20 h / 20 °C
4: 88 percent / NH3 / methanol / 16 h / 0 - 5 °C
5: 49 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
1: conc. NH4OH / dioxane / 24 h / 50 °C
2: N-methylimidazole (NMI) / pyridine / 0.5 h / 20 °C
3: 81 percent / 4-(dimethylamino)pyridine (DMAP), triethylamine / CH2Cl2 / 16 h
4: 66 percent / N-methylpyrrolidine, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / CH2Cl2 / 20 h / 20 °C
5: 88 percent / NH3 / methanol / 16 h / 0 - 5 °C
6: 49 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
1: 88 percent / pyridine / 1 h / 20 °C
2: conc. NH4OH / dioxane / 24 h / 50 °C
3: N-methylimidazole (NMI) / pyridine / 0.5 h / 20 °C
4: 81 percent / 4-(dimethylamino)pyridine (DMAP), triethylamine / CH2Cl2 / 16 h
5: 66 percent / N-methylpyrrolidine, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / CH2Cl2 / 20 h / 20 °C
6: 88 percent / NH3 / methanol / 16 h / 0 - 5 °C
7: 49 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
反应条件
1: 81 percent / 4-(dimethylamino)pyridine (DMAP), triethylamine / CH2Cl2 / 16 h
2: 66 percent / N-methylpyrrolidine, 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / CH2Cl2 / 20 h / 20 °C
3: 88 percent / NH3 / methanol / 16 h / 0 - 5 °C
4: 49 percent / TFA / CH2Cl2 / 0.17 h
View Scheme
参考文献
Roelen, H. C. P. F.; Brugghe, H. F.; Elst, H. van den; Klein, J. C.; Marel, G. A. van der; Boom, J. H. van
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, p. 227 - 234
