2,2-二甲基环丙烷甲酰氯合成路线 （共 9 条）
反应条件
ammonia in diethyl ether 2 h;
参考文献
Wills, Max T.; Wills, Irene E.; Dollen, Lawrence Von; Butler, Barry L.; Porter, John; Anderson, Arthur G.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2489 - 2498
参考文献
Wills, Max T.; Wills, Irene E.; Dollen, Lawrence Von; Butler, Barry L.; Porter, John; Anderson, Arthur G.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2489 - 2498
反应条件
1: With thionyl chloride in hexane
2.5 h; RefluxLarge scale;
2: T=135 - 140°C; 3 h; Inert atmosphereLarge scale;
参考文献
Zheng, Ren-Chao; Yang, Zhong-Yi; Li, Cong-Cheng; Zheng, Yu-Guo; Shen, Yin-Chu
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 102, p. 161 - 166
反应条件
1: 77 percent / KMnO4; KOH / H2O / 2 h / Heating
View Scheme
参考文献
Allen; Fenwick; Henry-Riyad; Tidwell
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5759 - 5765
反应条件
1: 80 percent / zinc-copper; I2 / diethyl ether / 35 °C
2: 77 percent / KMnO4; KOH / H2O / 2 h / Heating
View Scheme
参考文献
Allen; Fenwick; Henry-Riyad; Tidwell
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5759 - 5765
反应条件
1: 85 percent / NaOH / H2O / 48 h / Heating
2: 89 percent / Thionyl chloride
View Scheme
参考文献
Wills, Max T.; Wills, Irene E.; Dollen, Lawrence Von; Butler, Barry L.; Porter, John; Anderson, Arthur G.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2489 - 2498
反应条件
1: 71 percent / ethane-1,2-diol / 2 h / Heating
2: 85 percent / NaOH / H2O / 48 h / Heating
3: 89 percent / Thionyl chloride
View Scheme
参考文献
Wills, Max T.; Wills, Irene E.; Dollen, Lawrence Von; Butler, Barry L.; Porter, John; Anderson, Arthur G.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2489 - 2498
反应条件
1: 96 percent / pyridine
2: 71 percent / ethane-1,2-diol / 2 h / Heating
3: 85 percent / NaOH / H2O / 48 h / Heating
4: 89 percent / Thionyl chloride
View Scheme
参考文献
Wills, Max T.; Wills, Irene E.; Dollen, Lawrence Von; Butler, Barry L.; Porter, John; Anderson, Arthur G.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2489 - 2498
反应条件
in dichloromethane
T=20°C; 2 h;
参考文献
CHOONGWAE PHARMA CORPORATION; CHEMICO LTD.; CHIROAD INC.
Patent: WO2007/69841 A1, 2007 ;
Location in patent: Page/Page column 9 ;
