1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=0°C; 2 h; 2: With water; ammonium chloride in tetrahydrofuran; hexane T=0°C; regioselective reaction;

sodium sulfate; scandium tris(trifluoromethanesulfonate) in N,N-dimethyl-formamide T=100°C; 20 h; Schlenk techniqueInert atmosphereGreen chemistry;

1: 81 percent / t-BuONa / Pd2(dba)3, BINAP / toluene / 90 - 100 °C 2: 84 percent 3: 84 percent / LDA / tetrahydrofuran View Scheme

1: 81 percent / t-BuONa / Pd2(dba)3, BINAP / toluene / 90 - 100 °C 2: 84 percent 3: 84 percent / LDA / tetrahydrofuran View Scheme

1.1: copper diacetate; sodium acetate / water / |Reflux 2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / |Cooling with ice 2.2: 2 h / 80 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 100 °C 5.1: scandium tris(trifluoromethanesulfonate); sodium sulfate / N,N-dimethyl-formamide / 20 h / 100 °C / |Schlenk technique; |Inert atmosphere; |Green chemistry View Scheme

1.1: copper diacetate; sodium acetate / water / |Reflux 2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / |Cooling with ice 2.2: 2 h / 80 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 100 °C 5.1: scandium tris(trifluoromethanesulfonate); sodium sulfate / N,N-dimethyl-formamide / 20 h / 100 °C / |Schlenk technique; |Inert atmosphere; |Green chemistry View Scheme

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 100 °C 2: scandium tris(trifluoromethanesulfonate); sodium sulfate / N,N-dimethyl-formamide / 20 h / 100 °C / |Schlenk technique; |Inert atmosphere; |Green chemistry View Scheme

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 100 °C 3: scandium tris(trifluoromethanesulfonate); sodium sulfate / N,N-dimethyl-formamide / 20 h / 100 °C / |Schlenk technique; |Inert atmosphere; |Green chemistry View Scheme

1: 84 percent 2: 84 percent / LDA / tetrahydrofuran View Scheme

1.1: cesium fluoride / acetonitrile / 10 h / 65 °C 2.1: hydrogenchloride; water / acetonitrile / 2 h / 100 °C 2.2: 2 h / 100 °C View Scheme