反应条件
1: sodium iodide / acetone / 8 h / Heating 2: potassium carbonate / acetonitrile / 10 h / Heating 3: 2.) n-BuLi / tetrahydrofuran / 0.5 h / -78 - -30 °C / 1.) acetonitrile, reflux, 10 h; 2.) THF, from -78 deg C to -30 deg C, 30 min 4: hexamethylphosphoric acid triamide / 1.) -78 deg C, 30 min; 2.) from -78 deg C to 0 deg C, 90 min 5: 2.) lithium aluminum hydride / 1.) tosylation; View Scheme
参考文献
Manna, Sukumar; Falck, J. R.; Chacos, N.; Capdevila, J.
Tetrahedron Letters, 1983 , vol. 24, # 1 p. 33 - 36
