2-甲基巯基-5-溴嘧啶-4-甲酸甲酯合成路线 （共 4 条）
反应条件
sulfuric acid 24 h; Reflux;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; HOELDER, Swen; BLAGG, Julian; SOLANKI, Savade; WOODWARD, Hannah; NAUD, Sebastian; BAVETSIAS, Vassilios; SHELDRAKE, Peter; INNOCENTI, Paolo; CHEUNG, Jack; ATRASH, Butrus
Patent: WO2014/37750 A1, 2014 ;
Location in patent: Paragraph 00149; 0046-0050 ;
反应条件
1: methanol With acetyl chloride T=0 - 5°C; 0.0833333 h; 2: 5-bromo-2-(methylthio)pyrimidine-4-carboxylic acid T=0 - 5°C; 1 h; Heating / reflux;
参考文献
Pierre, Fabrice; O'Brien, Sean E.; Haddach, Mustapha; Bourbon, Pauline; Schwaebe, Michael K.; Stefan, Eric; Darjania, Levan; Stansfield, Ryan; Ho, Caroline; Siddiqui-Jain, Adam; Streiner, Nicole; Rice, William G.; Anderes, Kenna; Ryckman, David M.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1687 - 1691
参考文献
Pierre, Fabrice; O'Brien, Sean E.; Haddach, Mustapha; Bourbon, Pauline; Schwaebe, Michael K.; Stefan, Eric; Darjania, Levan; Stansfield, Ryan; Ho, Caroline; Siddiqui-Jain, Adam; Streiner, Nicole; Rice, William G.; Anderes, Kenna; Ryckman, David M.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1687 - 1691
反应条件
1: methyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate With 3-chloro-benzenecarboperoxoic acid in dichloromethane T=20°C; 1 h; 2: N-methylamine hydrochloride With N-ethyl-N,N-diisopropylamine in tetrahydrofuran; dichloromethane T=20°C;
参考文献
CHUA, Peter C.; Haddach, Mustapha; Nagasawa, Johnny Y.; Pierre, Fabrice; Whitten, Jeffrey P.
Patent: US2009/239859 A1, 2009 ;
Location in patent: Page/Page column 44 ;
US 20090239859 A1
