1-甲基-5-氨基-1H-吲唑合成路线 （共 5 条）
反应条件
iron; ammonium chloride in ethanol; water T=80°C; 1 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/88478 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 42 percent / KOH; water / 0.5 h / 75 °C 2: 11 percent / conc. HCl; SnCl2*H2O / methanol / Heating View Scheme
参考文献
Boyer, Gerard; Galy, Jean-Pierre; Faure, Robert; Elguero, Jose; Barbe, Jacques
Journal of Chemical Research, Miniprint, 1990 , # 11 p. 2601 - 2615
反应条件
hydrogenchloride; tin(ll) chloride in methanol Heating;
参考文献
Miloudi, Abdellah; El Abed, Douniazed; Boyer, Gerard; Galy, Jean-Pierre
Heterocycles, 2006 , vol. 68, # 12 p. 2595 - 2605
反应条件
phosphoric acid in water T=20 - 180°C; 18 h;
参考文献
SYNGENTA LIMITED
Patent: WO2004/108663 A1, 2004 ;
Location in patent: Page 106-107 ;
反应条件
1: With sulfuric acid; sodium nitrite in water T=0°C; 0.166667 h; 2: With sodium iodide in water T=0 - 90°C; 0.333333 h; 3: With sodium hydroxide; water
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/128009 A2, 2008 ;
Location in patent: Page/Page column 47-48 ;
WO 2008/128009 A2
