2-氯-1H-吲哚-3-甲醛合成路线 （共 28 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 1 h;
参考文献
Mortimer, Danny; Whiting, Matthew; Harrity, Joseph P.A.; Jones, Simon; Coldham, Iain
Tetrahedron Letters, 2014 , vol. 55, # 6 p. 1255 - 1257
反应条件
pyridine in acetone T=20°C; 16 h; Inert atmosphereIrradiation;
参考文献
Wang, Cailin; Zhang, Wei; Lu, Shenci; Wu, Jingfei; Shi, Zongjun
Chemical Communications, 2008 , # 41 p. 5176 - 5178
反应条件
1: 2-chloroindole-3-carboxaldehyde With sodium hydride in DMF (N,N-dimethyl-formamide) 0.666667 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) T=20°C; 3 h;
参考文献
Aventis Pharmaceuticals Inc.
Patent: US2005/54631 A1, 2005 ;
Location in patent: Page/Page column 17 ;
参考文献
Monge; Palop; Ramirez; Font; Fernandez-Alvarez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 2 p. 179 - 188
反应条件
1: potassium carbonate / acetone / 10 h / |Reflux
2: copper diacetate; pyridine / acetone / 25 h / 20 °C / |UV-irradiation
View Scheme
参考文献
Zhang, Wei; Dai, Yisi; Zhang, Wenxue; Wang, Kongchen; Wang, Weixia
Tetrahedron, 2013 , vol. 69, # 7 p. 1912 - 1918
参考文献
Engqvist, Robert; Bergman, Jan
Organic Preparations and Procedures International, 2004 , vol. 36, # 4 p. 386 - 390
反应条件
1: 76 percent / 0.25 h / Heating
2: 76 percent / N-methylaniline / 3 h / Heating
View Scheme
参考文献
Engqvist, Robert; Bergman, Jan
Organic Preparations and Procedures International, 2004 , vol. 36, # 4 p. 386 - 390
反应条件
sodium hydride
1.) DMF, mineral oil; 2.) DMF; Multistep reaction;
参考文献
Gatti, R.; Cavrini, V.; Roveri, P.; Bianucci, F.; Legnani, P.
Farmaco, Edizione Scientifica, 1981 , vol. 36, # 2 p. 102 - 108
反应条件
sodium hydride
1.) DMF, mineral oil; 2.) DMF; Yield given. Multistep reaction;
参考文献
Gatti, R.; Cavrini, V.; Roveri, P.; Bianucci, F.; Legnani, P.
Farmaco, Edizione Scientifica, 1981 , vol. 36, # 2 p. 102 - 108
反应条件
1.1: 97 percent / NaH; KH / tetrahydrofuran / Heating
2.1: tetrahydrofuran
2.2: 96 percent / TPAP; NMO
View Scheme
参考文献
Deng; Konopelski
Organic letters, 2001 , vol. 3, # 19 p. 3001 - 3004
