1-(4-溴苯基)-2,5-二甲基-1H-吡咯合成路线 （共 14 条）
反应条件
acetic acid in benzene 4 h; Heating;
参考文献
Aghapoor, Kioumars; Ebadi-Nia, Leila; Mohsenzadeh, Farshid; Mohebi Morad, Mina; Balavar, Yadollah; Darabi, Hossein Reza
Journal of Organometallic Chemistry, 2012 , vol. 708-709, p. 25 - 30
反应条件
in toluene T=80°C; 8 h; Inert atmosphere;
参考文献
Lee, Hyunseung; Kim, Byeong Hyo
Tetrahedron, 2013 , vol. 69, # 32 p. 6698 - 6708
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=20°C; 0.25 h; Inert atmosphere; 2: 4-(2,5-dimethylpyrrol-1-yl)-bromobenzene T=100°C; Vilsmeier-Haack Formylation; 3 h; Inert atmosphere;
参考文献
Murugesan, Dinakaran; Mital, Alka; Kaiser, Marcel; Shackleford, David M.; Morizzi, Julia; Katneni, Kasiram; Campbell, Michael; Hudson, Alan; Charman, Susan A.; Yeates, Clive; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2975 - 2990
反应条件
1: 93 percent / n-BuLi / hexane; diethyl ether / 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h 2: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 3: HgCl2 / methanol; H2O / 4 h / Heating 4: KOH / methanol / 2 h / Heating 5: H2NOH*HCl / ethanol; H2O / 24 h / Heating 6: H2SO4 / 3 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
potassium hydroxide; hydroxylamine hydrochloride in ethanol; water 24 h; Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2801 - 2807
反应条件
1: 93 percent / n-BuLi / hexane; diethyl ether / 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h 2: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 3: HgCl2 / methanol; H2O / 4 h / Heating 4: KOH / methanol / 2 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
n-butyllithium in diethyl ether; hexane 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h;
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
n-butyllithium in diethyl ether; hexane 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h;
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
in benzene 4 h; Heating;
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 93 percent / n-BuLi / hexane; diethyl ether / 1.) -20 deg C, 50 min, 2.) - 20 deg C, 1 h, 3.) 2 h 2: 74 percent / n-BuLi / hexane; tetrahydrofuran / 1.) -20 deg C --> 0 deg C, 45 min, 2.) 12 h 3: HgCl2 / methanol; H2O / 4 h / Heating 4: KOH / methanol / 2 h / Heating 5: 83 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 6: H2NOH*HCl / ethanol; H2O / 24 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
