2-氯-N4-甲基嘧啶-3,4-二胺合成路线 （共 7 条）
反应条件
hydrogen trioxochlorate(V); tin(ll) chloride in water T=90°C; 3 h; Heating / reflux;
参考文献
ALTANA PHARMA AG
Patent: WO2005/26164 A1, 2005 ;
Location in patent: Page/Page column 42 ;
反应条件
hydrogenchloride; NaH; stannous chloride in N-methyl-acetamide
参考文献
Merck Patent Gesellschaft Mit Beschrankter Haftung
Patent: US4654350 A1, 1987 ;
反应条件
in methanol; ammonium hydroxide; water
参考文献
American Home Products Corporation
Patent: US5723468 A1, 1998 ;
US 5723468 A
反应条件
hydrogenchloride in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Minetti, Patrizia; Tinti, Maria Ornella; Carminati, Paolo; Castorina, Massimo; Di Cesare, Maria Assunta; Di Serio, Stefano; Gallo, Grazia; Ghirardi, Orlando; Giorgi, Fabrizio; Giorgi, Luca; Piersanti, Giovanni; Bartoccini, Francesca; Tarzia, Giorgio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 6887 - 6896
参考文献
American Home Products Corporation
Patent: US5723468 A1, 1998 ;
US 5723468 A
反应条件
1.1: 68 percent / aq. HCl / dimethylformamide / 12 h / 20 °C
2.1: BuLi / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 64 percent / Br2 / hexane; tetrahydrofuran / 2 h / -78 °C
View Scheme
参考文献
Minetti, Patrizia; Tinti, Maria Ornella; Carminati, Paolo; Castorina, Massimo; Di Cesare, Maria Assunta; Di Serio, Stefano; Gallo, Grazia; Ghirardi, Orlando; Giorgi, Fabrizio; Giorgi, Luca; Piersanti, Giovanni; Bartoccini, Francesca; Tarzia, Giorgio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 6887 - 6896
反应条件
in acetonitrile
T=20 - 50°C; 56 h;
参考文献
Eisai Co., Ltd.
Patent: EP1568699 A1, 2005 ;
Location in patent: Page/Page column 82-83 ;
